Leishmanicidal Activity and Ultrastructural Changes of Maslinic Acid Isolated from Hyptidendron canum

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAdriana Jesus, Jéssica-
Autor(es): dc.creatorLaurenti, Márcia Dalastra-
Autor(es): dc.creatorLopes Silva, Matheus-
Autor(es): dc.creatorGhilardi Lago, João Henrique-
Autor(es): dc.creatorDomingues Passero, Luiz Felipe-
Data de aceite: dc.date.accessioned2025-08-21T18:53:44Z-
Data de disponibilização: dc.date.available2025-08-21T18:53:44Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2021/9970983-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/228980-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/228980-
Descrição: dc.descriptionThe therapeutic arsenal for the treatment of leishmaniasis is limited and has serious obstacles, such as variable activity, high toxicity, and costs. To overcome such limitations, it becomes urgent to characterize new bioactive molecules. Plants produce and accumulate different classes of bioactive compounds, and these molecules can be studied as a strategy to combat leishmaniasis. The study presented herein evaluated the leishmanicidal effect of maslinic acid isolated from the leaves of Hyptidendron canum (Lamiaceae) and investigated the morphological that occurred on Leishmania (Leishmania) infantum upon treatment. Maslinic acid was active and selective against promastigote and amastigote forms in a dose-dependent manner. Additionally, it was not toxic to peritoneal macrophages isolated from golden hamsters, while miltefosine and amphotericin B showed mild toxicity for macrophages. Morphological changes in promastigotes of L. (L.) infantum treated with maslinic acid were related to cytoplasmic degeneration, intense exocytic activity, and blebbing in the kDNA; disruption of mitochondrial cristae was observed in some parasites. The nucleus of promastigote forms seems to be degraded and the chromatin fragmented, suggesting that maslinic acid triggers programmed cell death. These results indicate that maslinic acid may be an interesting molecule to develop new classes of drugs against leishmaniasis.-
Descrição: dc.descriptionLaboratory of Pathology of Infectious Diseases (LIM50) Department of Pathology Medical School of São Paulo University, Av. Dr. Arnaldo, 455. Cerqueira, SP-
Descrição: dc.descriptionCentre of Natural and Human Sciences Federal University of ABC (UFABC)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences São Vicente. Praça Infante Dom Henrique S/n SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute for Advanced Studies of Ocean, São Vicente. João Francisco Bensdorp, SP 1178-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences São Vicente. Praça Infante Dom Henrique S/n SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute for Advanced Studies of Ocean, São Vicente. João Francisco Bensdorp, SP 1178-
Idioma: dc.languageen-
Relação: dc.relationEvidence-based Complementary and Alternative Medicine-
???dc.source???: dc.sourceScopus-
Título: dc.titleLeishmanicidal Activity and Ultrastructural Changes of Maslinic Acid Isolated from Hyptidendron canum-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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