5-HT neurons of the medullary raphe contribute to respiratory control in toads

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Goias at Jataí-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFonseca, Elisa M.-
Autor(es): dc.creatorNoronha-de-Souza, Carolina R.-
Autor(es): dc.creatorBícego, Kênia C.-
Autor(es): dc.creatorBranco, Luiz G.S.-
Autor(es): dc.creatorGargaglioni, Luciane H.-
Data de aceite: dc.date.accessioned2025-08-21T17:15:18Z-
Data de disponibilização: dc.date.available2025-08-21T17:15:18Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.resp.2021.103717-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/228973-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/228973-
Descrição: dc.descriptionAir-breathing vertebrates undergo respiratory adjustments when faced with disturbances in the gas composition of the environment. In mammals, the medullary raphe nuclei are involved in the neuronal pathway that mediates the ventilatory responses to hypoxia and hypercarbia. We investigate whether the serotoninergic neurons of the medullary raphe nuclei of toads (Rhinella diptycha) play a functional role in respiratory control during resting conditions (room air), hypercarbia (5% CO2), and hypoxia (5% O2). The raphe nuclei were located and identified based on the location of the serotoninergic neurons in the brainstem. We then lesioned the medullary raphe (raphe pallidus, obscurus and magnus) with anti-SERT-SAP and measured ventilation in both control and lesioned groups and we observed that serotonin (5-HT) specific chemical lesions of the medullary raphe caused reduced respiratory responses to both hypercarbia and hypoxia. In summary, we report that the serotoninergic neurons of the medullary raphe of the cururu toad Rhinella diptycha participate in the chemoreflex responses during hypercarbia and hypoxia, but not during resting conditions. This current evidence in anurans, together with the available data in mammals, brings insights to the evolution of brain sites, such as the medullary raphe, involved in the ventilatory chemoreflex in vertebrates.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology São Paulo State University - FCAV at Jaboticabal-
Descrição: dc.descriptionDepartment of Morphophysiology Federal University of Goias at Jataí-
Descrição: dc.descriptionDepartment of Basic and Oral Biology Dental School of Ribeirao Preto University of Sao Paulo-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology São Paulo State University - FCAV at Jaboticabal-
Descrição: dc.descriptionCNPq: 407490/2018-3-
Idioma: dc.languageen-
Relação: dc.relationRespiratory Physiology and Neurobiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjecthypercarbia-
Palavras-chave: dc.subjecthypoxia-
Palavras-chave: dc.subjectraphe nuclei-
Palavras-chave: dc.subjectserotonin-
Palavras-chave: dc.subjecttoads-
Palavras-chave: dc.subjectventilation-
Título: dc.title5-HT neurons of the medullary raphe contribute to respiratory control in toads-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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