Immunogenicity in Oreochromis niloticus vaccinated with sonicated antigens against streptococcosis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of the Jequitinhonha and Mucuri Valleys-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUFOPA-
Autor(es): dc.contributorScientific University of the South-
Autor(es): dc.contributorSea Institute of Peru-
Autor(es): dc.contributorFederal University of Roraima (UFRR)-
Autor(es): dc.contributorVeterinary Pathologist Autonomous-
Autor(es): dc.contributorState University of Northern Paraná. Bandeirantes-
Autor(es): dc.creatorMarcusso, Paulo Fernandes-
Autor(es): dc.creatorda Silva Claudiano, Gustavo-
Autor(es): dc.creatorYunis-Aguinaga, Jefferson-
Autor(es): dc.creatorde Almeida Marinho-Neto, Fausto-
Autor(es): dc.creatorEto, Silas Fernandes-
Autor(es): dc.creatorFernandes, Dayanne Carla-
Autor(es): dc.creatorRosolem, Mayara Caroline-
Autor(es): dc.creatorSalvador, Rogério-
Autor(es): dc.creatorEngracia de Moraes, Julieta Rodini-
Autor(es): dc.creatorRuas de Moraes, Flávio-
Data de aceite: dc.date.accessioned2025-08-21T22:09:39Z-
Data de disponibilização: dc.date.available2025-08-21T22:09:39Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.fsi.2021.04.030-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/228970-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/228970-
Descrição: dc.descriptionStreptococcosis causes great economic losses in intensive culture of tilapia. Vaccination is the most effective and safest way to tackle infectious diseases. Thus, this study sought the more effective and safer antigenic fraction after sonication of Streptococcus agalactiae to elaborate a vaccine against streptococcosis in Nile tilapia. For this, twenty-one days after vaccination with different fractions (soluble and insoluble) of S. agalactiae, the fish were challenged with the homologous strain (LD50). Then, samples were taken at zero, 14, 28, 60 and 90 days post-vaccination (DPV, n = 7). Blood and organs (cranial kidney, spleen and liver) were collected from vaccinated and unvaccinated fish. Finally, insoluble fraction vaccine presented the best effect, resulting in a 100% relative percent of survival (RPS) and without clinical manifestations. In view of the results, it was to evaluate the role of the insoluble fraction of the antigen in the protective immunity against streptococcosis. The results indicate that the spleen might be the main organ in the vaccine response in Nile tilapia due to the great morphological and immunological differences in vaccinated fish, evidenced by the greater of melanomacrophage centers (MMC) and IgM + lymphocytes in relation to the non-vaccinated fish. At 60 DPV, it was observed the peak of the protective immunity related to the maximum concentration of proteins, circulating leukocytes, antibody titers in the serum and tissue changes with greater expression of IgM + and MMC number in the spleen and kidney of Oreochromis niloticus. Vaccination with insoluble fraction of S. agalactiae was safe and provided effective protection against streptococcosis with maximum protective response at 60 DPV.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCanada's Michael Smith Genome Sciences Centre-
Descrição: dc.descriptionInstitute of Agricultural Sciences Federal University of the Jequitinhonha and Mucuri Valleys-
Descrição: dc.descriptionDepartment of Pathology Theriogenology and One Health Faculty of Agrarian and Veterinarian Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biodiversity and Forests Federal University of Western Pará UFOPA-
Descrição: dc.descriptionScientific University of the South-
Descrição: dc.descriptionSea Institute of Peru-
Descrição: dc.descriptionPostgraduated Program in Aquaculture/Aquaculture Center São Paulo State University (UNESP) Jaboticabal-
Descrição: dc.descriptionDepartment of Postgraduate in Health Sciences—PROCISA Federal University of Roraima (UFRR)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (Unesp)-
Descrição: dc.descriptionVeterinary Pathologist Autonomous-
Descrição: dc.descriptionState University of Northern Paraná. Bandeirantes-
Descrição: dc.descriptionDepartment of Pathology Theriogenology and One Health Faculty of Agrarian and Veterinarian Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionPostgraduated Program in Aquaculture/Aquaculture Center São Paulo State University (UNESP) Jaboticabal-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (Unesp)-
Formato: dc.format134-141-
Idioma: dc.languageen-
Relação: dc.relationFish and Shellfish Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectImmunity-
Palavras-chave: dc.subjectImmunopathology-
Palavras-chave: dc.subjectImmunoprophylaxis-
Palavras-chave: dc.subjectNile tilapia-
Palavras-chave: dc.subjectStreptococcosis-
Palavras-chave: dc.subjectVaccination-
Título: dc.titleImmunogenicity in Oreochromis niloticus vaccinated with sonicated antigens against streptococcosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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