An easy and low-cost biomagnetic methodology to study regional gastrointestinal transit in rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.creatorPinto, Leonardo-
Autor(es): dc.creatorSoares, Guilherme-
Autor(es): dc.creatorPróspero, André-
Autor(es): dc.creatorStoppa, Erick-
Autor(es): dc.creatorBiasotti, Gabriel-
Autor(es): dc.creatorPaixão, Fabiano-
Autor(es): dc.creatorSantos, Armênio-
Autor(es): dc.creatorOliveira, Ricardo-
Autor(es): dc.creatorMiranda, José-
Data de aceite: dc.date.accessioned2025-08-21T21:49:57Z-
Data de disponibilização: dc.date.available2025-08-21T21:49:57Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1515/bmt-2020-0202-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/228902-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/228902-
Descrição: dc.descriptionThe identification of gastrointestinal (GI) motility disorders requires the evaluation of regional GI transit, and the development of alternative methodologies in animals has a significant impact on translational approaches. Therefore, the purpose of this study was to validate an easy and low-cost methodology (alternate current biosusceptometry-ACB) for the assessment of regional GI transit in rats through images. Rats were fed a test meal containing magnetic tracer and phenol red, and GI segments (stomach, proximal, medial and distal small intestine, and cecum) were collected to assess tracer's retention at distinct times after ingestion (0, 60, 120, 240, and 360 min). Images were obtained by scanning the segments, and phenol red concentration was determined by the sample's absorbance. The temporal retention profile, geometric center, gastric emptying, and cecum arrival were evaluated. The correlation coefficient between methods was 0.802, and the temporal retention of each segment was successfully assessed. GI parameters yielded comparable results between methods, and ACB images presented advantages as the possibility to visualize intrasegmental tracer distribution and the automated scan of the segments. The imaging approach provided a reliable assessment of several parameters simultaneously and may serve as an accurate and sensitive approach for regional GI research in rats.-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology São Paulo State University Biosciences Institute of Botucatu, Prof. Antonio Celso Wagner Zanin Street-
Descrição: dc.descriptionScience and Technology Institute Federal University of São Paulo-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology Federal University of Ceará-
Descrição: dc.descriptionRibeirão Preto Medical School São Paulo University-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology São Paulo State University Biosciences Institute of Botucatu, Prof. Antonio Celso Wagner Zanin Street-
Formato: dc.format405-412-
Idioma: dc.languageen-
Relação: dc.relationBiomedizinische Technik-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlternate current biosusceptometry-
Palavras-chave: dc.subjectMagnetic imaging-
Palavras-chave: dc.subjectPhenol red-
Título: dc.titleAn easy and low-cost biomagnetic methodology to study regional gastrointestinal transit in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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