Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorHospital Perola Byington-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCavagna, Felipe-
Autor(es): dc.creatorPontes, A.-
Autor(es): dc.creatorCavagna, M.-
Autor(es): dc.creatorDzik, A.-
Autor(es): dc.creatorDonadio, N. F.-
Autor(es): dc.creatorPortela, R.-
Autor(es): dc.creatorNagai, M. T.-
Autor(es): dc.creatorGebrim, L. H.-
Data de aceite: dc.date.accessioned2025-08-21T21:21:29Z-
Data de disponibilização: dc.date.available2025-08-21T21:21:29Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2018-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3747/co.25.3889-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/228649-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/228649-
Descrição: dc.descriptionBackground Fertility preservation is an important concern in breast cancer patients. In the present investigation, we set out to create a specific protocol of controlled ovarian stimulation (cos) for oocyte cryopreservation in breast cancer patients. Methods From November 2014 to December 2016, 109 patients were studied. The patients were assigned to a specific random-start ovarian stimulation protocol for oocyte cryopreservation. The endpoints were the numbers of oocytes retrieved and of mature oocytes cryopreserved, the total number of days of ovarian stimulation, the total dose of gonadotropin administered, and the estradiol level on the day of the trigger. Results Mean age in this cohort was 31.27 ± 4.23 years. The average duration of cos was 10.0 ± 1.39 days. The mean number of oocytes collected was 11.62 ± 7.96 and the mean number of vitrified oocytes was 9.60 ± 6.87. The mean estradiol concentration on triggering day was 706.30 ± 450.48 pg/mL, and the mean dose of gonadotropins administered was 2610.00 ± 716.51 IU. When comparing outcomes by phase of the cycle in which cos was commenced, we observed no significant differences in the numbers of oocytes collected and vitrified, the length of ovarian stimulation, and the estradiol level on trigger day. The total dose of follicle-stimulating hormone and human menopausal gonadotropin administered was statistically greater in the group starting cos in the luteal phase than in the group starting in the late follicular phase. Conclusions Our results suggest that using a specific protocol with random-start ovarian stimulation for oocyte cryopreservation in breast cancer patients is effective and could be offered to young women undergoing oncologic treatment.-
Descrição: dc.descriptionWomen’s Health Reference Center Hospital Perola Byington-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School University of the State of Sao Paulo-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School University of the State of Sao Paulo-
Formato: dc.formate527-e532-
Idioma: dc.languageen-
Relação: dc.relationCurrent Oncology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBreast cancer-
Palavras-chave: dc.subjectFertility preservation-
Palavras-chave: dc.subjectOocyte cryopreservation-
Palavras-chave: dc.subjectOvarian stimulation-
Título: dc.titleSpecific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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