The influence of obesity by a diet high in saturated fats and carbohydrates balance in the manifestation of systemic complications and comorbidities

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAdorni, Caroline Soares-
Autor(es): dc.creatorCorrêa, Camila Renata-
Autor(es): dc.creatorVileigas, Danielle Fernandes-
Autor(es): dc.creatorde Campos, Dijon Henrique Salomé-
Autor(es): dc.creatorPadovani, Carlos Roberto-
Autor(es): dc.creatorMinatel, Igor Otávio-
Autor(es): dc.creatorCicogna, Antonio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T20:26:45Z-
Data de disponibilização: dc.date.available2025-08-21T20:26:45Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2017-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s41110-017-0042-1-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/228636-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/228636-
Descrição: dc.descriptionBackground: The aim of this study is to test the hypothesis that obesity induced by a diet rich in saturated fats and balanced in carbohydrates is associated with the development of systemic complications and comorbidities. Methods: Thirty-seven 60-day-old male Wistar rats were randomized into two groups: control (C, n = 18, standard diet) and obese (OB, n = 19, high-saturated fat diet), for 33 weeks. Nutritional profile: food and caloric intake, feed efficiency, body weight, and adiposity index. Complications: in plasma were analyzed dyslipidemia, insulin resistance (HOMA-IR), glucose intolerance, hyperleptinemia, hyperinsulinemia, plasmatic C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α); in the myocardial and epididymal adipose tissue were assessed IL-6 and TNF-α. Comorbidities: diabetes mellitus and systemic blood pressure (SBP). Student’s t test, ANOVA, and Bonferroni P < 0.05. Results: The final body weight, feed efficiency, and adiposity index were higher in OB group than in control; although food intake was lower in OB group, caloric intake was similar in both groups. Specific parameters, such as LDL, cholesterol, triglycerides, HOMA-IR, CRP, TNF-α in epididymal adipose tissue, and IL-6 in the myocardium, were higher in obese rats than in controls. SBP, baseline glucose, and glucose after 2 h of overload were significantly increased in OB group; however, the severity was not enough to classify the animals as diabetic and hypertensive. Conclusion: Obesity induced by a diet high in saturated fatty acids with balanced carbohydrates for 33 weeks in Wistar rats was effective in triggering complications but unable to develop comorbidities.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University-
Descrição: dc.descriptionDepartment of Pathology Botucatu School of Medicine São Paulo State University–UNESP, Distrito de Rubião Jr s/n-
Descrição: dc.descriptionDepartment of Biostatistics Botucatu Biosciences Institute São Paulo State University-
Descrição: dc.descriptionDepartment of Biochemistry Botucatu Biosciences Institute São Paulo State University-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University-
Descrição: dc.descriptionDepartment of Pathology Botucatu School of Medicine São Paulo State University–UNESP, Distrito de Rubião Jr s/n-
Descrição: dc.descriptionDepartment of Biostatistics Botucatu Biosciences Institute São Paulo State University-
Descrição: dc.descriptionDepartment of Biochemistry Botucatu Biosciences Institute São Paulo State University-
Descrição: dc.descriptionFAPESP: 2012/25094-5-
Idioma: dc.languageen-
Relação: dc.relationNutrire-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectComorbidities-
Palavras-chave: dc.subjectComplications-
Palavras-chave: dc.subjectDiet-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectRat-
Título: dc.titleThe influence of obesity by a diet high in saturated fats and carbohydrates balance in the manifestation of systemic complications and comorbidities-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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