Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAlbert Einstein College of Medicine-
Autor(es): dc.contributorGeorge Washington School of Medicine and Health Sciences-
Autor(es): dc.creatorCosta-Orlandi, Caroline B.-
Autor(es): dc.creatorMordorski, Breanne-
Autor(es): dc.creatorBaltazar, Ludmila M.-
Autor(es): dc.creatorMendes-Giannini, Maria José S.-
Autor(es): dc.creatorFriedman, Joel M.-
Autor(es): dc.creatorNosanchuk, Joshua D.-
Autor(es): dc.creatorFriedman, Adam J.-
Data de aceite: dc.date.accessioned2025-08-21T18:48:37Z-
Data de disponibilização: dc.date.available2025-08-21T18:48:37Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2018-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/228606-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/228606-
Descrição: dc.descriptionTopical antimicrobials are the ideal mode of onychomycosis treatment for efficient drug delivery and avoidance of sytemic effects associated with oral medications. However, high treatment costs, tissue penetration limitations, and low cure rates have continued to pose major challenges. To capitalize on the progress made by topical efinaconazole solution, efinaconazole was combined with inexpensive, previously-characterized nitric oxide releasing nanoparticles (NO-np), which have been shown to offer sustained nitric oxide release over time and enhanced barrier penetration, while exerting broad spectrum antimicrobial and immunomodulating properties. NO-np were combined with efinaconazole in varying concentrations and applied against reference strains of Trichophyton rubrum using a checkerboard method. Results demonstrated synergism of NO-np+efinaconazole against T. rubrum, which is noteworthy given the barriers present in the topical treatment of onychomycosis, and the multiple potential benefits offered by NO-np. Overall, this study illustrates the untapped potential of nanotechnology in the treatment of disorders of the skin, hair, and nails where drug delivery remains a challenge.-
Descrição: dc.descriptionDepartment of Clinical Analysis Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas-
Descrição: dc.descriptionDepartment of Medicine Division of Infectious Diseases Albert Einstein College of Medicine-
Descrição: dc.descriptionDepartment of Medicine Division of Dermatology Albert Einstein College of Medicine-
Descrição: dc.descriptionDepartment of Physiology and Biophysics Albert Einstein College of Medicine-
Descrição: dc.descriptionDepartment of Dermatology George Washington School of Medicine and Health Sciences-
Descrição: dc.descriptionDepartment of Clinical Analysis Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas-
Formato: dc.format717-720-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drugs in Dermatology-
???dc.source???: dc.sourceScopus-
Título: dc.titleNitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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