Heart remodeling produced by aortic stenosis promotes cardiomyocyte apoptosis mediated by collagen V imbalance

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSant'Ana, Paula Grippa-
Autor(es): dc.creatorBatah, Sabrina Setembre-
Autor(es): dc.creatorLeão, Patrícia Santos-
Autor(es): dc.creatorTeodoro, Walcy Rosolia-
Autor(es): dc.creatorde Souza, Sérgio Luiz Borges-
Autor(es): dc.creatorFerreira Mota, Gustavo Augusto-
Autor(es): dc.creatorVileigas, Danielle Fernandes-
Autor(es): dc.creatorda Silva, Vitor Loureiro-
Autor(es): dc.creatorde Campos, Dijon Henrique Salomé-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorCapelozzi, Vera Luiza-
Autor(es): dc.creatorCicogna, Antonio Carlos-
Autor(es): dc.creatorFabro, Alexandre Todorovic-
Data de aceite: dc.date.accessioned2025-08-21T20:21:14Z-
Data de disponibilização: dc.date.available2025-08-21T20:21:14Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2018-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pathophys.2018.07.001-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/228560-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/228560-
Descrição: dc.descriptionCardiac remodeling (CR) is a structural change of the heart due to chronic hemodynamic overload related to changes in both myocyte and extracellular matrix (ECM). We investigated that the imbalance of collagen V promotes cardiomyocyte apoptosis that contributes to heart failure and cell death. Aortic stenosis was induced surgically and male Wistar rats were randomized to 18 weeks (Sham 18 w, n = 12; AoS 18 w, n = 12) and severe of heart failure (Sham HF, n = 12; AoS HF, n = 12) groups. Functional and structural echocardiogram, immunohistochemistry for Ki-67, TUNEL assay and Immunofluorescence for collagen were performed. Our main results were: (1) Progressive reduction of cardiac functional capacity due to cardiac remodeling with decreased eject fraction in heart failure; (2) Imbalance of collagen deposition with increased, crowded and irregular collagen I in situ expression; (3) Dysregulation of dynamic control of collagen fibers with exposed epitopes of collagen V; (4) Additional apoptosis that are dependent to cardiac injury. The collagen V expression in cardiac remodeling is for the first time described and may be related to additional apoptosis and autoimmune response. Our findings suggest a critical role of collagen V in cardiac remodeling to modulate and promote heart failure and death.-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University-
Descrição: dc.descriptionDepartment of Pathology and Legal Medicine Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Pathology Faculty of Medicine University of São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University-
Formato: dc.format373-379-
Idioma: dc.languageen-
Relação: dc.relationPathophysiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAortic stenosis-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectCardiac remodeling-
Palavras-chave: dc.subjectCollagen V-
Título: dc.titleHeart remodeling produced by aortic stenosis promotes cardiomyocyte apoptosis mediated by collagen V imbalance-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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