Reinkes'edema: Immunoexpression study of fibronectin, laminin and colagen IV in 60 cases by imunohistochemical techniques

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMartins, Regina Helena Garcia-
Autor(es): dc.creatorDomingues, Maria Aparecida-
Autor(es): dc.creatorFabro, Alexandre Todorovic-
Autor(es): dc.creatorDias, Norimar Hernandes-
Autor(es): dc.creatorSantana, Marcela Ferreira-
Data de aceite: dc.date.accessioned2025-08-21T16:18:36Z-
Data de disponibilização: dc.date.available2025-08-21T16:18:36Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2009-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/S1808-8694(15)30543-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/228552-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/228552-
Descrição: dc.descriptionReinke's edema is chronic laryngeal disease in which the superficial layer of the lamina propria is expanded by thick mucus, giving it a gelatin aspect. The disease is directly related to smoking and more frequent in women, who end up having a lower tone of voice. Its histological characteristics cannot always distinguish it from other benign lesions of the larynx for which additional histological techniques are necessary. Aim: to study the immunoexpression of fibronectin, collagen IV and laminin in Reinke's edema by immunohistochemical technique. Prospective study. Materials and methods: histological blocks of 60 cases of surgical Reinke's edema were saved, submitted to new cross-sections and to immunohistochemical reactions for fibronectin, laminin and collagen IV by the Avidin-Biotin-Peroxidase method. Fragments of five normal vocal folds were used as control, removed during autopsy. All patients were chronic smokers and adults- 50 women and 10 men. Results: the immunoexpression of fibronectin, collagen IV and laminin was more important in the endothelium of blood vessels (68.33%, 76.66%, 73.33%, respectively) and less relevant in the basement membrane (25.0%, 5.0% and 3.3%, respectively). Conclusions: the immunoexpression of fibronectin, laminin and of collagen IV in the basal membrane of Reinke's edema was not relevant, with a predominance of these antibodies in the endothelium of blood vessels. © Revista Brasileira de Otorrinolaringologia. All Rights reserved.-
Descrição: dc.descriptionMedical School of Botucatu Unesp-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Paulista State University -Unesp Botucatu Campus-
Descrição: dc.descriptionDepartment of Pathology Unesp-
Descrição: dc.descriptionUnesp-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Unesp, Botucatu-
Descrição: dc.descriptionMedical School of Botucatu Unesp-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Paulista State University -Unesp Botucatu Campus-
Descrição: dc.descriptionDepartment of Pathology Unesp-
Descrição: dc.descriptionUnesp-
Descrição: dc.descriptionDepartment of Otorhinolaryngology Unesp, Botucatu-
Formato: dc.format821-825-
Idioma: dc.languageen-
Idioma: dc.languagept_BR-
Relação: dc.relationBrazilian Journal of Otorhinolaryngology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFibronectins-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectLaminin-
Palavras-chave: dc.subjectLaryngeal edema-
Palavras-chave: dc.subjectType iv collagen-
Título: dc.titleReinkes'edema: Immunoexpression study of fibronectin, laminin and colagen IV in 60 cases by imunohistochemical techniques-
Título: dc.titleEdema de Reinke: Estudo da imunoexpressão da fibronectina, da laminina e do colágeno IV em 60 casos por meio de técnicas imunoistoquímicas-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.