Influence of TLR-2 in the immune response in the infection induced by fungus Sporothrix schenckii

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorNegrini, Thais De C.-
Autor(es): dc.creatorFerreira, Lucas S.-
Autor(es): dc.creatorArthur, Rodrigo A.-
Autor(es): dc.creatorAlegranci, Pâmela-
Autor(es): dc.creatorPlaceres, Marisa C. P.-
Autor(es): dc.creatorSpolidorio, Luis C.-
Autor(es): dc.creatorCarlos, Iracilda Z.-
Data de aceite: dc.date.accessioned2025-08-21T20:09:49Z-
Data de disponibilização: dc.date.available2025-08-21T20:09:49Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2014-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3109/08820139.2013.879174-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/227688-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/227688-
Descrição: dc.descriptionToll-like receptors (TLRs) play an important role in immunity, since they bind to pathogen surface antigens and initiate the immune response. However, little is known about the role of TLR-2 in the recognition of S. schenckii and in the subsequent immune response. Therefore, the aim of this study was to evaluate the involvement of TLR-2 in the immune response induced by S. schenckii. C57BL/6 mice (WT) and C57BL/6 TLR-2 knockout (TLR-2-/-) were used to evaluate, over a period of 10 weeks of sporotrichotic infection, the influence of TLR-2 over macrophages production of IL-1β, IL-12 and TNF-α, their stimulation level by NO release and the production of IFN-γ, IL-6, IL-17 and TGF-β by spleen cells. The results showed that the production of pro-inflammatory mediators and NO, TLR-2 interference is striking, since its absence completely inhibited it. IL-17 production was independent of TLR-2. The absence of Th1 response in TLR2-/- animals was concomitant with IL-17 production. Therefore, it can be suggested that TLR-2 absence interferes with the course of the infection induced by the fungus S. schenckii. © 2014 Informa Healthcare USA, Inc.-
Descrição: dc.descriptionDepartment of Clinical Analysis, Araraquara School of Pharmaceutical Sciences, São Paulo State University, Rua Expedicionários do Brasil, no 1621, Araraquara, SP, CEP 14.801-902-
Descrição: dc.descriptionDepartment of Preventive and Community Dentistry, School of Dentistry, Federal University of Rio Grande Do sul, RS-
Descrição: dc.descriptionDepartment of Physiology and Pathology, Araraquara School of Dentistry, São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Clinical Analysis, Araraquara School of Pharmaceutical Sciences, São Paulo State University, Rua Expedicionários do Brasil, no 1621, Araraquara, SP, CEP 14.801-902-
Descrição: dc.descriptionDepartment of Physiology and Pathology, Araraquara School of Dentistry, São Paulo State University, SP-
Formato: dc.format370-390-
Idioma: dc.languageen-
Relação: dc.relationImmunological Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectMice-
Palavras-chave: dc.subjectSporothrix schenckii-
Palavras-chave: dc.subjectSporotrichosis-
Palavras-chave: dc.subjectTLR-2-
Título: dc.titleInfluence of TLR-2 in the immune response in the infection induced by fungus Sporothrix schenckii-
Tipo de arquivo: dc.typelivro digital-
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