Parâmetros metabólicos de ratos propensos a demonstrarem corrida selvagem devido a crises audiogênicas e brigas induzidas por privação de sono REM

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMoraes, Gabriel Parmezani-
Autor(es): dc.creatorRafacho, Alex-
Autor(es): dc.creatorBosqueiro, José Roberto-
Autor(es): dc.creatorHoshino, Katsumasa-
Autor(es): dc.creatorde Paula, Hugo Medeiros Garrido-
Data de aceite: dc.date.accessioned2025-08-21T21:16:25Z-
Data de disponibilização: dc.date.available2025-08-21T21:16:25Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2010-12-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/227508-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/227508-
Descrição: dc.descriptionObjective: Total sleep or selective REM-sleep deprivation (SD) increases aggressiveness. Rats that display fighting when submitted to sleep-deprivation are those that manifest wild running (WR), a panic-like flight that precedes tonic-clonic seizures induced by intense acoustic stimulation (audiogenic epilepsy). The incidence of WR-sensitive rats in the colonies around the world may reach 20%, which makes important to know the other characteristics of these animals for both sleep and other kinds of experimental research. Based on the report of their reduced body weight, we investigated some glucose metabolism parameters. Methods: Adult male Wistar rats were submitted to high-intensity acoustic stimulation (112dB, 60s) and then classified as WR-sensitive or WR-resistant rats. Glycemia and insulinemia, measured by glucometer and radioimmunoassay, respectively, and body weight were analyzed during three months. At the end of this period, intraperitoneal glucose and insulin tolerance tests were performed, and hepatic fat and glycogen content were also determined. Results: WR-sensitive rats showed proportionally less gain of body mass compared to the resistant ones (p<0.05) in initial measurements, but this tendency did not sustain thereafter. Interestingly, fasting glycemia was significantly lower in the WR-sensitive group throughout the experiment, compared to WR-resistant rats. No significant differences between groups were found in insulinemia, peripheral glucose and insulin tolerance, and hepatic glycogen. However, WR-sensitive rats increased hepatic fat content significantly after a 12-hour fasting. Conclusions: Slow weight gain, decreased fasting glycemia and hepatic steatosis suggest a possible accelerated energetic metabolism or low resistance to food deprivation, which could partially explain the reduced body weight of WR-sensitive rats.-
Descrição: dc.descriptionDepartment of Biological Sciences Universidade Estadual Paulista 'Júlio de Mesquita Filho' UNESP, Bauru (SP)-
Descrição: dc.descriptionDepartment of Physical Education Universidade Estadual Paulista 'Júlio de Mesquita Filho' UNESP, Bauru (SP)-
Descrição: dc.descriptionDepartment of Biological Sciences Universidade Estadual Paulista 'Júlio de Mesquita Filho' UNESP, Bauru (SP)-
Descrição: dc.descriptionDepartment of Physical Education Universidade Estadual Paulista 'Júlio de Mesquita Filho' UNESP, Bauru (SP)-
Formato: dc.format74-81-
Idioma: dc.languageen-
Idioma: dc.languagept_BR-
Relação: dc.relationSleep Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcoustic stimulation-
Palavras-chave: dc.subjectAdipose tissue/metabolism-
Palavras-chave: dc.subjectAggression-
Palavras-chave: dc.subjectAnimals-
Palavras-chave: dc.subjectBlood glucose/metabolism-
Palavras-chave: dc.subjectBody weight-
Palavras-chave: dc.subjectEnergy metabolism/physiology-
Palavras-chave: dc.subjectEpilepsy-
Palavras-chave: dc.subjectLactic acid/blood-
Palavras-chave: dc.subjectMetabolism-
Palavras-chave: dc.subjectPanic/physiology-
Palavras-chave: dc.subjectRats-
Palavras-chave: dc.subjectReflex/physiopathology-
Palavras-chave: dc.subjectRunning-
Palavras-chave: dc.subjectSeizures/metabolism-
Palavras-chave: dc.subjectSleep deprivation-
Palavras-chave: dc.subjectSleep deprivation/physiopathology-
Palavras-chave: dc.subjectWistar-
Título: dc.titleParâmetros metabólicos de ratos propensos a demonstrarem corrida selvagem devido a crises audiogênicas e brigas induzidas por privação de sono REM-
Título: dc.titleMetabolic parameters of rats prone to display wild-running of the audiogenic crisis and fights induced by REM-sleep deprivation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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