Spontaneous canine transmissible venereal tumor: Association between different phenotypes and the insertion LINE-1/c-myc

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFonseca, Luciano S.-
Autor(es): dc.creatorMota, Lígia S.L.S.-
Autor(es): dc.creatorColodel, Marcia M.-
Autor(es): dc.creatorFerreira, Isabelle-
Autor(es): dc.creatorBrandão, Cláudia Valéria S-
Autor(es): dc.creatorRocha, Noeme S.-
Data de aceite: dc.date.accessioned2025-08-21T20:38:56Z-
Data de disponibilização: dc.date.available2025-08-21T20:38:56Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2012-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226981-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226981-
Descrição: dc.descriptionObjective: This study aimed to evaluate the LINE-1 transposon inserted in c-myc gene as a specific genetic alteration in cells of spontaneous canine Transmissible Venereal Tumor (TVT) with either lymphocytoid or plasmacytoid phenotypes. Methods: Tumoral biopsies from 35 dogs were collected by puncture or exfoliation. Polymerase Chain Reaction (PCR) was carried out with primers myc.s and LINE. A, specific to the LINE-1 segment to detect the presence of LINE-1/c-myc molecular marker. Results: Sequence alignment of DNA samples from lymphocytoid and plasmacytoid TVT cells did not show polymorphisms, and the comparison with sequences from the GenBank identified them as a LINE-1/c-myc rearrangement. Conclusions: Considering the aggressive nature of the plasmacytoid phenotype, there is no apparent relation between LINE-1/c-myc and the malignancy of TVT. Further studies are needed to establish molecular differences associated with the aggressiveness of the various phenotypes of canine TVT.-
Descrição: dc.descriptionDepartment of Clinical Veterinary Medicine School of Veterinary Medicine and Animal Science (FMVZ) State University of São Paulo (UNESP), Botucatu-
Descrição: dc.descriptionDepartment de Genetics Institute of Biosciences State University of São Paulo (UNESP), Botucatu-
Descrição: dc.descriptionDepartment of Surgery and Veterinary Anesthesiology School of Veterinary Medicine and Animal Science (FMVZ) State University of São Paulo (UNESP), Botucatu-
Descrição: dc.descriptionDepartment of Clinical Veterinary Medicine School of Veterinary Medicine and Animal Science (FMVZ) State University of São Paulo (UNESP), Botucatu-
Descrição: dc.descriptionDepartment de Genetics Institute of Biosciences State University of São Paulo (UNESP), Botucatu-
Descrição: dc.descriptionDepartment of Surgery and Veterinary Anesthesiology School of Veterinary Medicine and Animal Science (FMVZ) State University of São Paulo (UNESP), Botucatu-
Formato: dc.format402-408-
Idioma: dc.languageen-
Idioma: dc.languagees-
Relação: dc.relationRevista Colombiana de Ciencias Pecuarias-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDogs-
Palavras-chave: dc.subjectOncogenes-
Palavras-chave: dc.subjectPolymerase Chain Reaction-
Palavras-chave: dc.subjectTransposition elements-
Título: dc.titleSpontaneous canine transmissible venereal tumor: Association between different phenotypes and the insertion LINE-1/c-myc-
Título: dc.titleTumor venéreo transmisible canino espontáneo: Asociación entre diferentes fenotipos y la inserción LINE -1/c-myc-
Tipo de arquivo: dc.typelivro digital-
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