Influence of hydatidiform mole follow-up setting on postmolar gestational trophoblastic neoplasia outcomes a cohort study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Central de Venezuela-
Autor(es): dc.contributorBrigham and Women's Hospital and Massachusetts General Hospital-
Autor(es): dc.creatorDantas, PatrÍcia Rangel Sobral-
Autor(es): dc.creatorMaestá, Izildinha-
Autor(es): dc.creatorCortés-Charry, Rafael-
Autor(es): dc.creatorGrowdon, Whitfield B.-
Autor(es): dc.creatorBraga, Antonio-
Autor(es): dc.creatorRudge, Marilza Vieira Cunha-
Autor(es): dc.creatorBerkowitz, Ross S.-
Data de aceite: dc.date.accessioned2025-08-21T17:36:41Z-
Data de disponibilização: dc.date.available2025-08-21T17:36:41Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2012-08-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226955-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226955-
Descrição: dc.descriptionOBJECTIVE: To assess the influence of hydatidiform mole (HM) management setting (reference center versus other institutions) on gestational trophoblastic neoplasia (GTN) outcomes. METHODS: This cohort study included 270 HM patients attending Botucatu Trophoblastic Diseases Center (BTDC, São Paulo State University, Brazil) between January 1990 and December 2009 (204 undergoing evacuation and entire postmolar follow-up at BTDC and 66 from other institutions [OIs]). GTN characteristics and outcomes were analyzed and compared according to HM management setting. The confounding variables assessed included age, gravidity, parity, number of abortions and HM type (complete or partial). Postmolar GTN outcomes were compared using Mann-Whitney's test, χ2 test or Fisher's exact test. RESULTS: Postmolar GTN occurred in 34 (34/204= 16.7%) BTDC patients and in 27 (27/66=40.9%) of those initially treated in other institutions. BTDC patients showed lower metastasis rate (5.8% vs. 48%, p= 0.003) and lower median FIGO (2002) score (2.00 [1.00, 3.00] vs. 4.00 [2.00, 7.00], p=0.003]. Multiagent chemotherapy to treat postmolar GTN was required in 2 BTDC cases (5.9%) and in 8 OI cases (29.6%) (p = 0.017). Median time interval between molar evacuation and chemotherapy onset was shorter among BTDC patients (7.0 [6.0, 10.0] vs. 10.0 [7.0, 16.0], p=0.040). CONCLUSION: BTDC patients showed GTN characteristics indicative of better prognosis. This underscores the importance of GTD specialist centers. © Journal of Reproductive Medicine®, Inc.-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School São Paulo State University, UNESP, P.O. Box 530, CEP 18618-970, Botucatu, SP-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology Hospital Universitario de Caracas Universidad Central de Venezuela, Caracas-
Descrição: dc.descriptionThe Division of Gynecologic Oncology Department of Obstetrics and Gynecology, Harvard Medical School Brigham and Women's Hospital and Massachusetts General Hospital, Boston, MA-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School São Paulo State University, UNESP, P.O. Box 530, CEP 18618-970, Botucatu, SP-
Formato: dc.format305-309-
Idioma: dc.languageen-
Relação: dc.relationJournal of Reproductive Medicine for the Obstetrician and Gynecologist-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGestational trophoblastic neoplasia-
Palavras-chave: dc.subjectHydatidiform mole-
Palavras-chave: dc.subjectManagement setting-
Título: dc.titleInfluence of hydatidiform mole follow-up setting on postmolar gestational trophoblastic neoplasia outcomes a cohort study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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