In vivo models for measuring placental glutatione-stransferase (GST-P 7-7) levels: A suitable biomarker for understanding cancer pathogenesis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorNoguti, Juliana-
Autor(es): dc.creatorBarbisan, Luis Fernando-
Autor(es): dc.creatorCesar, Augusto-
Autor(es): dc.creatorSeabra, Camilo Dias-
Autor(es): dc.creatorChoueri, Rodrigo Brasil-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Data de aceite: dc.date.accessioned2025-08-21T19:17:51Z-
Data de disponibilização: dc.date.available2025-08-21T19:17:51Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2012-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226935-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226935-
Descrição: dc.descriptionThe Glutatione-S-transferases (GSTs) comprise a family of enzymes closely associated with the cell detoxification of xenobiotics. GSTs exist as homo- or heterodimers and have been grouped into at least seven distinct classes. The main function of GSTs is to catalyze the conjugation of reduced glutathione (GSH) to an electrophilic site of a broad range of potentially toxic and carcinogenic compounds, thereby making such compounds less dangerous and enabling their ready-excretion. Placental GST, known as GST-P 7-7, is the main isoform found in normal placental tissue and comprises 67% of the total GST concentration in this tissue. During development, GST-P 7-7 decreases in concentration and is absent in adult tissues. Interestingly, GST-P 7-7 expression has been detected in adult tissues after exposure to carcinogenic agents in several experimental test systems, being considered a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. In this article, we review a series of studies involving GST-P 7-7 expression as a suitable tool for understanding cancer pathogenesis, especially cancer risk.-
Descrição: dc.descriptionDepartment of Pathology Federal University of Sao Paulo UNIFESP, SP-
Descrição: dc.descriptionDepartment of Biosciences Federal University of Sao Paulo UNIFESP, SP-
Descrição: dc.descriptionDepartment of Morphology Sao Paulo State University UNESP, Botucatu, SP-
Descrição: dc.descriptionDepartment of Morphology Sao Paulo State University UNESP, Botucatu, SP-
Formato: dc.format647-650-
Idioma: dc.languageen-
Relação: dc.relationIn Vivo-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectGST-P 7-7-
Palavras-chave: dc.subjectIn vivo models-
Palavras-chave: dc.subjectReview-
Título: dc.titleIn vivo models for measuring placental glutatione-stransferase (GST-P 7-7) levels: A suitable biomarker for understanding cancer pathogenesis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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