Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAzevedo, Paula S.-
Autor(es): dc.creatorPolegato, Bertha F.-
Autor(es): dc.creatorMinicucci, Marcos F.-
Autor(es): dc.creatorPio, Stephan M.-
Autor(es): dc.creatorSilva, Igor A.-
Autor(es): dc.creatorSantos, Priscila P.-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorPaiva, Sergio A. R.-
Autor(es): dc.creatorZornoff, Leonardo A. M.-
Data de aceite: dc.date.accessioned2025-08-21T16:46:53Z-
Data de disponibilização: dc.date.available2025-08-21T16:46:53Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2012-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.12659/MSM.883202-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226893-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226893-
Descrição: dc.descriptionBackground: The objective of this study was to determine the early echocardiographic predictors of elevated left ventricular end-diastolic pressure (LVEDP) after a long follow-up period in the infarcted rat model. Material/Methods: Five days and three months after surgery, sham and infarcted animals were subjected to transthoracic echocardiography. Regression analysis and receiver-operating characteristic (ROC) curve were performed for predicting increased LVEDP 3 months after MI. Results: Among all of the variables, assessed 5 days after myocardial infarction, infarct size (OR: 0.760; CI 95% 0.563-0.900; p=0.005), end-systolic area (ESA) (OR: 0.761; CI 95% 0.564-0.900; p=0.008), fractional area change (FAC) (OR: 0.771; CI 95% 0.574-0.907; p=0.003), and posterior wall-shortening velocity (PWSV) (OR: 0.703; CI 95% 0.502-0.860; p=0.048) were predictors of increased LVEDP. The LVEDP was 3.6±1.8 mmHg in the control group and 9.4±7.8 mmHg among the infarcted animals (p=0.007). Considering the critical value of predictor variables in inducing cardiac dysfunction, the cut-off value was 35% for infarct size, 0.33 cm2 for ESA, 40% for FAC, and 26 mm/s for PWSV. Conclusions: Infarct size, FAC, ESA, and PWSV, assessed five days after myocardial infarction, can be used to estimate an increased LVEDP three months following the coronary occlusion. © Med Sci Monit.-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School UNESP, Botucatu-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School UNESP, Botucatu-
Idioma: dc.languageen-
Relação: dc.relationMedical Science Monitor-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCardiac function-
Palavras-chave: dc.subjectHeart failure-
Palavras-chave: dc.subjectRemodelingbr-
Título: dc.titleEarly echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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