Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Oliveira, Larissa Ragozo Cardoso-
Autor(es): dc.creatorPicka, M. C.M.-
Autor(es): dc.creatorNicolete, V. C.-
Autor(es): dc.creatorCalvi, S. A.-
Autor(es): dc.creatorMarcondes-Machado, J.-
Data de aceite: dc.date.accessioned2025-08-21T22:30:11Z-
Data de disponibilização: dc.date.available2025-08-21T22:30:11Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2012-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s1678-91992012000100005-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226757-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226757-
Descrição: dc.descriptionThe aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis. © CEVAP 2012.-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Formato: dc.format34-43-
Idioma: dc.languageen-
Relação: dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDistribution-
Palavras-chave: dc.subjectHemoculture-
Palavras-chave: dc.subjectOrgans-
Palavras-chave: dc.subjectPCR-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Título: dc.titleOrgan tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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