How can micelle systems be rebuilt by a heating process?

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of rio grande do Norte (UFrN)-
Autor(es): dc.contributorUFrN-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorda Silva-Filho, Miguel Adelino-
Autor(es): dc.creatorSiqueira, Scheyla Daniela Vieira da Silva-
Autor(es): dc.creatorFreire, Larissa Bandeira-
Autor(es): dc.creatorde Araújo, Ivonete Batista-
Autor(es): dc.creatorde Holandae e Silva, Káttya Gyselle-
Autor(es): dc.creatorda Medeiros, Aldo Cunha-
Autor(es): dc.creatorAraújo-Filho, Irami-
Autor(es): dc.creatorde Oliveira, Anselmo Gomes-
Autor(es): dc.creatordo Egito, Eryvaldo Sócrates Tabosa-
Data de aceite: dc.date.accessioned2025-08-21T20:41:01Z-
Data de disponibilização: dc.date.available2025-08-21T20:41:01Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2012-02-10-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226699-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226699-
Descrição: dc.descriptionThe aim of this work was to evaluate how an aqueous micellar system containing Amphotericin B (AmB) and sodium deoxycholate (DOC) can be rebuilt after heating treatment. Also, a review of the literature on the physicochemical and biological properties of this new system was conducted. Heated (AmB-DOC-H) and unheated (AmB-DOC) micelles were then diluted at four different concentrations (50 mg. L -1, 5 mg. L -1, 0.5 mg. L -1, and 0.05 mg. L -1) to perform physicochemical studies and a pharmacotoxicity assay, in which two cell models were used for the in vitro experiments: red blood cells (RBC) from human donors and Candida parapsilosis (Cp). While potassium (K +) and hemoglobin leakage from RBC were the parameters used to evaluate acute and chronic toxicity, respectively, the effcacy of AmB-DOC and AmB-DOC-H were assessed by K + leakage and cell survival rate from Cp. The spectral study revealed a slight change in the AmB-DOC aggregate peak from 327 nm to 323 nm, which is the peak for AmB-DOC-H. Although AmB-DOC and AmB-DOC-H exhibited different behavior for hemoglobin leakage, AmB-DOC produced higher leakage than AmB-DOC-H at high concentrations (from 5 mg. L -1). For K + leakage, both AmB-DOC and AmB-DOC-H showed a similar profle for both cell models, RBC and Cp (P < 0.05). AmB-DOC-H and AmB-DOC also revealed a similar profle of activity against Cp with an equivalent survival rate. In short, AmB-DOC-H showed much less toxicity than AmB-DOC, but remained as active as AmB-DOC against fungal cells. The results highlight the importance of this new procedure as a simple, inexpensive, and safe way to produce a new kind of micelle system for the treatment of systemic fungal infections. © 2012 Silva-Filho et al.-
Descrição: dc.descriptionDispersed Systems Laboratory Federal University of rio grande do Norte (UFrN), Rio grande do Norte, 8948 Natal-
Descrição: dc.descriptionDepartment of Pharmacy UFrN, Natal, Rio grande do Norte-
Descrição: dc.descriptionDepartment of experimental Surgery UFrN, Natal, rio grande do Norte-
Descrição: dc.descriptionDepartment of Drugs and Medicines College of Pharmaceutical Sciences (UNeSP), Araraquara, São Paulo-
Descrição: dc.descriptionDepartment of Drugs and Medicines College of Pharmaceutical Sciences (UNeSP), Araraquara, São Paulo-
Formato: dc.format141-150-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Nanomedicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMicelles-
Palavras-chave: dc.subjectNanotechnology-
Palavras-chave: dc.subjectPre-heated amphotericin B-
Palavras-chave: dc.subjectSuper-aggregates-
Título: dc.titleHow can micelle systems be rebuilt by a heating process?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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