Treatment of experimental periodontal disease with antimicrobial photodynamic therapy in nicotine-modified rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorDental School of Barretos-
Autor(es): dc.creatorGarcia, Valdir Gouveia-
Autor(es): dc.creatorFernandes, Leandro Araújo-
Autor(es): dc.creatorMacArini, Valmir Campos-
Autor(es): dc.creatorDe Almeida, Juliano Milanezi-
Autor(es): dc.creatorMartins, Thiago Marchi-
Autor(es): dc.creatorBosco, Alvaro Francisco-
Autor(es): dc.creatorNagata, Maria José Hitomi-
Autor(es): dc.creatorCirelli, Joni Augusto-
Autor(es): dc.creatorTheodoro, Letícia Helena-
Data de aceite: dc.date.accessioned2025-08-21T16:09:16Z-
Data de disponibilização: dc.date.available2025-08-21T16:09:16Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2011-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/j.1600-051X.2011.01785.x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226611-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226611-
Descrição: dc.descriptionBackground The aim of this study was to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive treatment to scaling and root planing (SRP) for induced periodontitis in nicotine-modified rats. Material & Methods A total of 240 rats were evenly divided into two groups: C - saline solution treatment; N - nicotine treatment. Periodontal disease was induced in both groups at the first mandibular molar. After 7 days, the ligature was removed. All animals were submitted to SRP and were divided according to the following treatments: SRP - irrigation with saline solution; Toluidine Blue-O (TBO) - irrigation with phenothiazinium dye (100 μg/ml); LLLT - laser irradiation (660 nm; 0.03 W; 4 J); and aPDT - TBO and laser irradiation. Ten animals in each group/treatment were euthanized at 7, 15 and 30 days. The histometric and immunohistochemical values were statistically analysed. Results Intragroup analysis demonstrated that in both groups the aPDT treatment resulted in lower bone loss (BL) when compared to SRP in all experimental periods. Intergroup analysis demonstrated that aPDT treatment resulted in lower BL in Group N than in Group C treated with SRP in all experimental periods. Conclusion Antimicrobial photodynamic therapy was an effective adjunctive treatment to SRP for induced periodontitis in nicotine-modified rats. © 2011 John Wiley & Sons A/S.-
Descrição: dc.descriptionGroup of Research and Study on Laser in Dentistry (GEPLO) Department of Surgery São Paulo State University, São Paulo, Araçatuba-
Descrição: dc.descriptionDepartment of Clinic and Surgery Federal University of Alfenas, Alfenas, MG-
Descrição: dc.descriptionUniversity Center of the Educational Foundation of Barretos (UNIFEB) Dental School of Barretos, Barretos, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Division of Periodontics São Paulo State University, São Paulo, Araraquara-
Descrição: dc.descriptionGroup of Research and Study on Laser in Dentistry (GEPLO) Department of Surgery São Paulo State University, São Paulo, Araçatuba-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Division of Periodontics São Paulo State University, São Paulo, Araraquara-
Formato: dc.format1106-1114-
Idioma: dc.languageen-
Relação: dc.relationJournal of Clinical Periodontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalveolar bone loss-
Palavras-chave: dc.subjectlasers-
Palavras-chave: dc.subjectnicotine-
Palavras-chave: dc.subjectosteoclasts-
Palavras-chave: dc.subjectperiodontitis-
Palavras-chave: dc.subjectphotochemotherapy-
Título: dc.titleTreatment of experimental periodontal disease with antimicrobial photodynamic therapy in nicotine-modified rats-
Tipo de arquivo: dc.typelivro digital-
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