Insulin signaling proteins in pancreatic islets of insulin-resistant rats induced by glucocorticoid

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.creatorde Paula, Flávia M.M-
Autor(es): dc.creatorBoschero, Antonio C-
Autor(es): dc.creatorCarneiro, Everardo M-
Autor(es): dc.creatorBosqueiro, José R-
Autor(es): dc.creatorRafacho, Alex-
Data de aceite: dc.date.accessioned2025-08-21T18:18:04Z-
Data de disponibilização: dc.date.available2025-08-21T18:18:04Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2011-11-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4067/S0716-97602011000300006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226597-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226597-
Descrição: dc.descriptionChronic administration of glucocorticoids induces insulin resistance that is compensated by an increase in β-cell function and mass. Since insulin signaling is involved in the control of β-cell function and mass, we investigated the content of insulin pathway proteins in pancreatic islets. Rats were made insulin resistant by daily administration of dexamethasone (1mg/kg, b.w., i.p.) for 5 consecutive days (DEX), whilst control rats received saline (CTL). Circulating insulin and insulin released from isolated islets were measured by radioimmunoassay whereas the content of proteins was analyzed by Western blotting. DEX rats were hyperinsulinemic and exhibited augmented insulin secretion in response to glucose (P < 0.01). The IRα-subunit, IRS-1, Shc, AKT, p-p70S6K, ERK1/2, p-ERK1/2, and glucocorticoid receptor protein levels were similar between DEX and CTL islets. However, the IRβ-subunit, p-IRβ-subunit, IRS-2, PI3-K, p-AKT and p70S6K protein contents were increased in DEX islets (P < 0.05). We conclude that IRS-2 may have a major role, among the immediate substrates of the insulin receptor, to link activated receptors to downstream signaling components related to islet function and growth in this insulin-resistant rat model.-
Descrição: dc.descriptionDepartment of Anatomy, Cell Biology and Physiology and Biophysics Institute of Biology Universidade Estadual de Campinas - UNICAMP, Campinas, SP-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences Universidade Estadual Paulista -UNESP, Bauru, SP-
Descrição: dc.descriptionDepartment of Physiological Sciences Center of Biological Sciences Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences Universidade Estadual Paulista -UNESP, Bauru, SP-
Formato: dc.format251-257-
Idioma: dc.languageen-
Relação: dc.relationBiological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDexamethasone-
Palavras-chave: dc.subjectGlucocorticoid-
Palavras-chave: dc.subjectInsulin resistance-
Palavras-chave: dc.subjectInsulin signaling-
Palavras-chave: dc.subjectPancreatic islets-
Título: dc.titleInsulin signaling proteins in pancreatic islets of insulin-resistant rats induced by glucocorticoid-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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