Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats?

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFernandes, Glaura S. A.-
Autor(es): dc.creatorGerardin, Daniela C. C.-
Autor(es): dc.creatorAssumpção, Thaiane A.-
Autor(es): dc.creatorCampos, Kleber E.-
Autor(es): dc.creatorDamasceno, Débora C.-
Autor(es): dc.creatorPereira, Oduvaldo C. M.-
Autor(es): dc.creatorKempinas, Wilma D. G.-
Data de aceite: dc.date.accessioned2025-08-21T17:22:59Z-
Data de disponibilização: dc.date.available2025-08-21T17:22:59Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2011-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/S1734-1140(11)70614-4-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226539-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226539-
Descrição: dc.descriptionDiabetic neuropathy can affect the male reproductive system. The aim of this study was therefore to evaluate whether antioxidant (vitamins C and/or E) treatment could attenuate reproductive dysfunctions in hyperglycemic adult male rats. The animals were randomly assigned to one of four experimental groups: hyperglycemic control (Hy), hyperglycemic + 150 mg/day vitamin C (HyC), hyperglycemic + 100 mg/day vitamin E (HyE) or hyperglycemic + vitamins C and E (HyCE). The normoglycemic group (n = 10) received only the vehicles. The testosterone level and noradrenergic response of the vas deferens were analyzed. Both vitamins significantly decreased the TBARS (thiobarbituric acid reactive species) level in the hyperglycemic groups. There was a significant reduction in the testosterone level in the Hy and HyE groups when compared to the normoglycemic group. However, the testosterone levels were partially recovered in the HyC and HyCE groups. In addition, an increased sensitivity of the α-1 adrenoceptor in the vas deferens of the hyperglycemic control group was observed. Treatment with vitamins partially restored (vitamin E or in combination with vitamin C) or totally (vitamin C alone) this dysfunction. Moreover, the maximum response values to norepinephrine were similar among all groups. Thus, we concluded that vitamin C is more efficient than vitamin E in attenuating the effects of hyperglycemia on the male reproductive system of adult rats. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.-
Descrição: dc.descriptionInstitute of Biology State University of Campinas -UNICAMP Cidade Universitária Zeferino Vaz, 13083-862, Campinas, SP-
Descrição: dc.descriptionDepartment of Physiological Sciences State University of Londrina Londrina - UEL, Celso Garcia Cid, 86051-980, Londrina, PR-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SP-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SP-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences UNESP - Univ. Estadual Paulista, Distrito de Rubião Jr. s/n, 18618-000, Botucatu, SP-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SP-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SP-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences UNESP - Univ. Estadual Paulista, Distrito de Rubião Jr. s/n, 18618-000, Botucatu, SP-
Formato: dc.format983-991-
Idioma: dc.languageen-
Relação: dc.relationPharmacological Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHyperglycemia-
Palavras-chave: dc.subjectMale rat-
Palavras-chave: dc.subjectMale reproductive system-
Palavras-chave: dc.subjectNorepinephrine-
Palavras-chave: dc.subjectTestosterone-
Palavras-chave: dc.subjectVas deferens-
Palavras-chave: dc.subjectVitamin C-
Palavras-chave: dc.subjectVitamin E-
Título: dc.titleCan vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.