Cytotoxicity of active ingredients extracted from plants of the Brazilian Cerrado

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUNIP-
Autor(es): dc.creatorSoares, Veronica C.G.-
Autor(es): dc.creatorBonacorsi, Cibele-
Autor(es): dc.creatorAndrela, Alana L.B.-
Autor(es): dc.creatorBortoloti, Lígia V.-
Autor(es): dc.creatorDe Campos, Stepheny C.-
Autor(es): dc.creatorFagundes, Fábio H.R.-
Autor(es): dc.creatorPiovani, Márcio-
Autor(es): dc.creatorCotrim, Camila A.-
Autor(es): dc.creatorVilegas, Wagner-
Autor(es): dc.creatorToyama, Marcos H.-
Data de aceite: dc.date.accessioned2025-08-21T20:52:28Z-
Data de disponibilização: dc.date.available2025-08-21T20:52:28Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2011-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/1934578x1100600714-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226529-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226529-
Descrição: dc.descriptionCytotoxicity assays are needed for the screening of natural products with potential anti-inflammatory. The purpose of this study was to compare the basal cytotoxicity of active ingredients extracted from plants of the Brazilian cerrado. The viability was assayed with the neutral red uptake assay in Mac Coy cells after 24h of exposition. The dose evaluated was 50 μg/μL. The test substances were: cinnamic acid, p-coumaric acid, chlorogenic acid, syringic acid, vannilic acid, homogentisic acid, scandenin, palustric acid, diosgenin, cabraleone. Studies of cytotoxicity demonstrated that all active compounds evaluated have low toxicity in vitro. The substances showed cell viability above 60% for the concentration used. However, the cinnamic acid, sacandenin and palustric acid showed highest toxicity with a 50% reduction in cell viability for the dose of 50 μg/μL. Cytotoxic screening results are useful to estimate the best concentrations of those compounds with potential anti-inflammatory without their cause cell death.-
Descrição: dc.descriptionInstitute of Biology UNICAMP, Campinas, Sao Paulo, 13083-862-
Descrição: dc.descriptionDepartment of Microbiology UNESP, Araraquara, Sao Paulo, 14801-902-
Descrição: dc.descriptionInstitute of Chemistry UNESP, Araraquara, Sao Paulo, 14801-970-
Descrição: dc.descriptionDepartment of Pharmacy, Unianchieta, Jundiai, Sao Paulo, 13207-270-
Descrição: dc.descriptionDepartment of Pharmacy UNIP, Jundiai, Sao Paulo, 13214-525-
Descrição: dc.descriptionInstitute of Biology UNESP Campus Litoral Paulista, Sao Vicente, Sao Paulo,11330-150-
Descrição: dc.descriptionDepartment of Microbiology UNESP, Araraquara, Sao Paulo, 14801-902-
Descrição: dc.descriptionInstitute of Chemistry UNESP, Araraquara, Sao Paulo, 14801-970-
Descrição: dc.descriptionInstitute of Biology UNESP Campus Litoral Paulista, Sao Vicente, Sao Paulo,11330-150-
Formato: dc.format983-984-
Idioma: dc.languageen-
Relação: dc.relationNatural Product Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBrazilian cerrado-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectNatural products-
Título: dc.titleCytotoxicity of active ingredients extracted from plants of the Brazilian Cerrado-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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