Renal- and calcium-dependent vascular effects of Polybia paulista wasp venom

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorVinhote, J. F.C.-
Autor(es): dc.creatorTorres, A. F.C.-
Autor(es): dc.creatorDantas, R. T.-
Autor(es): dc.creatorPraciano, T. P.-
Autor(es): dc.creatorMenezes, R. R.P.P.B.-
Autor(es): dc.creatorSousa, D. F.-
Autor(es): dc.creatorBrito, T. S.-
Autor(es): dc.creatorLima, F. J.B.-
Autor(es): dc.creatorToyama, M. H.-
Autor(es): dc.creatorMagalhães, P. J.-
Autor(es): dc.creatorMonteiro, H. A.S.-
Autor(es): dc.creatorMartins-Nunes, A. M.C.-
Data de aceite: dc.date.accessioned2025-08-21T16:35:41Z-
Data de disponibilização: dc.date.available2025-08-21T16:35:41Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2011-06-13-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1678-91992011000200011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226358-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226358-
Descrição: dc.descriptionIn the present study, the effects of Polybia paulista venom (PPV) on renal and vascular tissues were investigated. Isolated kidneys perfused with PPV (1 and 3 μg/mL) had increased perfusion pressure, renal vascular resistance, urinary flow, and glomerular filtration rate; and reduced sodium tubular transport. Histological evaluation demonstrated deposits of proteins in Bowman's space and tubular lumen, and focal areas of necrosis. The venom promoted a cytotoxic effect on Madin-Darby canine kidney (MDCK) cells. A significant increase in lactic dehydrogenase levels was observed in response to venom exposure. In isolated mesenteric vascular beds, pressure and vascular resistance augmented in a dose-dependent manner. PPV increased the contractility of aortic rings maintained under basal tension. This contractile response was inhibited when preparations were maintained in Ca2+-free medium. Likewise, verapamil, a voltage-gated calcium channel blocker, also inhibited the contractile response. In this study, phentolamine, a blocker of α-adrenergic receptor blocker, significantly reduced the contractile effect of PPV in the aortic ring. In conclusion, PPV produced nephrotoxicity, which suggests a direct effect on necrotic cellular death in renal tubule cells. The vascular contractile effect of PPV appears to involve calcium influx through voltage-gated calcium channels via adrenergic regulation. © CEVAP 2011.-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology Federal University of Ceará, Fortaleza-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses Federal University of Ceará, Fortaleza, Ceará State-
Descrição: dc.descriptionSão Paulo Experimental Coast Campus São Paulo State University (UNESP - Univ Estadual Paulista), São Vicente, São Paulo State-
Descrição: dc.descriptionSão Paulo Experimental Coast Campus São Paulo State University (UNESP - Univ Estadual Paulista), São Vicente, São Paulo State-
Formato: dc.format199-208-
Idioma: dc.languageen-
Relação: dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAorta-
Palavras-chave: dc.subjectKidney-
Palavras-chave: dc.subjectMDCK-
Palavras-chave: dc.subjectPolybia paulista-
Palavras-chave: dc.subjectVenom-
Título: dc.titleRenal- and calcium-dependent vascular effects of Polybia paulista wasp venom-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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