Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.creatorPontes, Davi A.-
Autor(es): dc.creatorFernandes, Glaura S. A.-
Autor(es): dc.creatorPiffer, Renata C.-
Autor(es): dc.creatorGerardin, Daniela C. C.-
Autor(es): dc.creatorPereira, Oduvaldo C. M.-
Autor(es): dc.creatorKempinas, Wilma G.-
Data de aceite: dc.date.accessioned2025-08-21T18:26:33Z-
Data de disponibilização: dc.date.available2025-08-21T18:26:33Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2011-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/S1734-1140(11)70407-8-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226287-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226287-
Descrição: dc.descriptionHyperglycemic and hypoinsulinemic states caused by diabetes mellitus are usually related to some type of sexual dysfunction, resulting in infertility in humans and experimental models, mostly due to their effects on ejaculatory function. This study aimed to evaluate the possible role of testosterone in the restoration of normal ejaculatory function in diabetic rats. Male Wistar rats were randomly allocated into 3 experimental groups: control, diabetic (streptozotocin), and diabetic with testosterone supplementation (streptozotocin plus testosterone). The following parameters were assessed at the end of the experiment: body weight, circulating testosterone levels, number of spermatozoa ejaculated in the uterus through natural mating, and weight and in vitro isometric contractions of the vas deferens. Diabetic rats showed reduced plasma testosterone levels and ejaculatory dysfunction as observed by a lack in the spermatozoa ejaculated into the uterus of receptive females. In these diabetic rats, no difference was observed in the sensitivity of the vas deferens to norepinephrine, with or without the presence of the cocktail (cocaine plus propranolol). In spite of this, an increased sensitivity to methoxamine through the α1-adrenoceptor was observed. Testosterone supplementation did not restore these parameters to control values. We conclude that, in this experimental model, the lack of testosterone was not directly related to the diabetes-induced ejaculatory dysfunction. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.-
Descrição: dc.descriptionGraduate Program in Cellular and Structural Biology Institute of Biology State University of Campinas - UNICAMP-
Descrição: dc.descriptionGraduate Program in Medical Clinics Botucatu School of Medicine UNESP - Univ Estadual Paulista-
Descrição: dc.descriptionBiological Sciences Center State University of Londrina UEL-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences of Botucatu UNESP - University Estadual Paulista-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences of Botucatu UNESP - University Estadual Paulista-
Descrição: dc.descriptionGraduate Program in Medical Clinics Botucatu School of Medicine UNESP - Univ Estadual Paulista-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences of Botucatu UNESP - University Estadual Paulista-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences of Botucatu UNESP - University Estadual Paulista-
Formato: dc.format130-138-
Idioma: dc.languageen-
Relação: dc.relationPharmacological Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDiabetes-
Palavras-chave: dc.subjectEjaculation-
Palavras-chave: dc.subjectInfertility-
Palavras-chave: dc.subjectNorepinephrine-
Palavras-chave: dc.subjectTestosterone-
Título: dc.titleEjaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.