Biochemical and biological evaluation of gyroxin isolated from Crotalus durissus terrificus venom

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorFluminense Federal University, UFF-
Autor(es): dc.creatorBarros, L. C.-
Autor(es): dc.creatorSoares, A. M.-
Autor(es): dc.creatorCosta, F. L.-
Autor(es): dc.creatorRodrigues, V. M.-
Autor(es): dc.creatorFuly, A. L.-
Autor(es): dc.creatorGiglio, J. R.-
Autor(es): dc.creatorGallacci, M.-
Autor(es): dc.creatorThomazini-Santos, I. A.-
Autor(es): dc.creatorBarraviera, S. C.R.S.-
Autor(es): dc.creatorBarraviera, B.-
Autor(es): dc.creatorFerreira, R. S.-
Data de aceite: dc.date.accessioned2025-08-21T22:37:36Z-
Data de disponibilização: dc.date.available2025-08-21T22:37:36Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2011-03-24-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1678-91992011000100004-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226268-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226268-
Descrição: dc.descriptionGyroxin, a thrombin-like enzyme isolated from Crotalus durissus terrificus venom and capable of converting fibrinogen into fibrin, presents coagulant and neurotoxic activities. The aim of the present study was to evaluate such coagulant and toxic properties. Gyroxin was isolated using only two chromatographic steps - namely gel filtration (Sephadex G-75) and affinity (Benzamidine Sepharose 6B) - resulting in a sample of high purity, as evaluated by RP-HPLC C2/C18 and electrophoretic analysis that showed a molecular mass of 30 kDa. Gyroxin hydrolyzed specific chromogenic substrates, which caused it to be classified as a serine proteinase and thrombin-like enzyme. It was stable from pH 5.5 to 8.5 and inhibited by Mn2+, Cu2+, PMSF and benzamidine. Human plasma coagulation was more efficient at pH 6.0. An in vivo toxicity test showed that only behavioral alterations occurred, with no barrel rotation. Gyroxin was not able to block neuromuscular contraction in vitro, which suggests that its action, at the studied concentrations, has no effect on the peripheral nervous system.© CEVAP 2011.-
Descrição: dc.descriptionDepartment of Tropical Diseases and Imaging Diagnosis Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Descrição: dc.descriptionDepartment of Clinical Toxicological and Bromatological Analysis School of Pharmaceutical Sciences, University of São Paulo, USP, Ribeirão Preto, São Paulo State-
Descrição: dc.descriptionInstitute of Genetics and Biochemistry Federal University of Uberlândia, Uberlândia, Minas Gerais State-
Descrição: dc.descriptionDepartment of Cellular and Molecular Biology Institute of Biology Fluminense Federal University, UFF, Niterói, Rio de Janeiro State-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology Medical School of Ribeirão Preto University of São Paulo, USP, Ribeirão Preto, São Paulo State-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biology São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Descrição: dc.descriptionDepartment of Dermatology Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Descrição: dc.descriptionDepartment of Tropical Diseases and Imaging Diagnosis Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biology São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Descrição: dc.descriptionDepartment of Dermatology Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State-
Formato: dc.format23-33-
Idioma: dc.languageen-
Relação: dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCoagulant activity-
Palavras-chave: dc.subjectCrotalus durissus terrificus-
Palavras-chave: dc.subjectGyroxin-
Palavras-chave: dc.subjectNeurotoxicity-
Palavras-chave: dc.subjectSerine proteinase-
Título: dc.titleBiochemical and biological evaluation of gyroxin isolated from Crotalus durissus terrificus venom-
Tipo de arquivo: dc.typelivro digital-
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