Influence of glycerol and ornithine feeding on clavulanic acid production by streptomyces clavuligerus

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTeodoro, J. C.-
Autor(es): dc.creatorBaptista-Neto, A.-
Autor(es): dc.creatorAraujo, M. L.G.C.-
Autor(es): dc.creatorHokka, C. O.-
Autor(es): dc.creatorBadino, A. C.-
Data de aceite: dc.date.accessioned2025-08-21T22:40:30Z-
Data de disponibilização: dc.date.available2025-08-21T22:40:30Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2010-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S0104-66322010000400001-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226205-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226205-
Descrição: dc.descriptionThe influence of glycerol and ornithine feeding on clavulanic acid (CA) production by Streptomyces clavuligerus was investigated. In batch experiments, CA maximum concentration (Cpmax) ranged randomly from 430 to 560 mg.L-1, with a maximum increase of 10% in relation to the control run, without ornithine. However, the maximum volumetric productivity of CA (Ppmax) of 13.7 mg.L-1.h-1 was obtained with 0.66 g.L-1 of ornithine, 44.2% higher than the Ppmax in the control run. In fed-batch experiments, Cpmax varied within the narrow range from 1.254 to 1.405 g.L-1, 2.5 times higher than that obtained in the control run. The presence of ornithine increased the Pp max, although it influenced only slightly the Cpmax. Concerning glycerol, the highest CA production of 1.6 g.L-1 was obtained in the fed-batch with glycerol and ornithine (180 and 3.7 g.L -1) in a 10-L bioreactor, showing a positive effect of ornithine and glycerol, in the proper proportion (48.6:1), on CA biosynthesis.-
Descrição: dc.descriptionUFSCar Federal University of São Carlos Department of Chemical Engineering, Rod. Washington Luiz, 13565-905, São Carlos - SP-
Descrição: dc.descriptionUNESP Institute of Chemistry Department of Biochemistry and Technological Chemistry, Rua Prof. Francisco Degni s/n, 14800-900, Araraquara - SP-
Descrição: dc.descriptionUNESP Institute of Chemistry Department of Biochemistry and Technological Chemistry, Rua Prof. Francisco Degni s/n, 14800-900, Araraquara - SP-
Formato: dc.format499-506-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Chemical Engineering-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectClavulanic acid-
Palavras-chave: dc.subjectFed-batch-
Palavras-chave: dc.subjectGlycerol-
Palavras-chave: dc.subjectOrnithine-
Palavras-chave: dc.subjectStreptomyces clavuligerus-
Título: dc.titleInfluence of glycerol and ornithine feeding on clavulanic acid production by streptomyces clavuligerus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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