K+ATP channels-independent analgesic action of Crotalus durissus cumanensis venom

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Ceara-
Autor(es): dc.contributorFortaleza University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPereira, Ticiana Praciano-
Autor(es): dc.creatorCampos, Adriana Rolim-
Autor(es): dc.creatorLeal, Luzia Kalyne A. M.-
Autor(es): dc.creatorPierdoná, Taiana Magalhães-
Autor(es): dc.creatorToyama, Marcos H.-
Autor(es): dc.creatorMonteiro, Helena Serra Azul-
Autor(es): dc.creatorMartins, Alice Maria Costa-
Data de aceite: dc.date.accessioned2025-08-21T21:35:32Z-
Data de disponibilização: dc.date.available2025-08-21T21:35:32Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2010-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/1934578x1000500725-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/226032-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/226032-
Descrição: dc.descriptionThe effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 μg/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 μg/kg) was unaffected by the ATP-sensitive K+ channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+ channels pathway is not contributable to the antinociceptive mechanism of CDCM.-
Descrição: dc.descriptionDepartment of Pharmacy Federal University of Ceara, Fortaleza, Ceara-
Descrição: dc.descriptionVice-Rectory of Research and Post-Graduation Fortaleza University, Fortaleza, Ceara-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology Federal University of Ceara, Fortaleza, Ceara-
Descrição: dc.descriptionSão Vicente United Campus of Litoral Paulista Paulista State University, Sao Paulo, Sao Paulo-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses Federal University of Ceara, Fortaleza, Ceara-
Descrição: dc.descriptionSão Vicente United Campus of Litoral Paulista Paulista State University, Sao Paulo, Sao Paulo-
Formato: dc.format1103-1106-
Idioma: dc.languageen-
Relação: dc.relationNatural Product Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCrotalus durissus cumanensis venom-
Palavras-chave: dc.subjectGlibenclamide-
Palavras-chave: dc.subjectNociception-
Título: dc.titleK+ATP channels-independent analgesic action of Crotalus durissus cumanensis venom-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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