Inhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae)

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorCAC-UFG-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorGuararapuava - UNICENTRO-
Autor(es): dc.creatorPetacci, Fernando-
Autor(es): dc.creatorFreitas, Silvia S.-
Autor(es): dc.creatorBrunetti, Iguatemy L.-
Autor(es): dc.creatorKhalil, Najeh M.-
Data de aceite: dc.date.accessioned2025-08-21T16:27:09Z-
Data de disponibilização: dc.date.available2025-08-21T16:27:09Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2010-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4067/S0716-97602010000100008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225895-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225895-
Descrição: dc.descriptionAstilbin (5,7,3',4'-tetrahydroxy-2,3-dihydroflavonol-3-β-o-rhamnoside), a flavonoid with a large range of biological activities, was isolated from Dimorphandra mollis, a shrub common to the Brazilian Cerrado. The purpose of this study is to verify the effects of astilbin on myeloperoxidase (MPO) and horseradish peroxidase (HRP), and its antioxidant activity against hypochlorous acid (HOCl) and total antioxidant activity (TAC) by the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS•+). Astilbin inhibited MPO and HRP activities in a concentration-dependent relationship and effectively scavenged HOCl. The TAC by ABTS•+ of astilbin (IC50 ~ 20 mM) was higher than that of uric acid, which was used as a positive control. These data demonstrate that astilbin is a potent antioxidant and that it inhibits MPO and HRP activities efficiently.-
Descrição: dc.descriptionChemistry Department CAC-UFG, Catalão, Goiás-
Descrição: dc.descriptionClinical Analysis Department School of Pharmaceutical Sciences Araraquara - UNESP - São Paulo State University, São Paulo-
Descrição: dc.descriptionPharmacy Department Guararapuava - UNICENTRO, Paraná-
Descrição: dc.descriptionClinical Analysis Department School of Pharmaceutical Sciences Araraquara - UNESP - São Paulo State University, São Paulo-
Formato: dc.format63-74-
Idioma: dc.languageen-
Relação: dc.relationBiological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAstilbin-
Palavras-chave: dc.subjectHorseradish peroxidase-
Palavras-chave: dc.subjectHypochlorous acid-
Palavras-chave: dc.subjectMyeloperoxidase-
Palavras-chave: dc.subjectReactive oxygen species-
Título: dc.titleInhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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