Inhibitory effect of gallic acid and its esters on 2,2'-azobis(2- amidinopropane)hydrochloride (AAPH)-induced hemolysis and depletion of intracellular glutathione in erythrocytes

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorXimenes, Valdecir F.-
Autor(es): dc.creatorLopes, Mariana G.-
Autor(es): dc.creatorPetrônio, Maicon Segalla-
Autor(es): dc.creatorRegasini, Luis Octavio-
Autor(es): dc.creatorSiqueira Silva, Dulce H.-
Autor(es): dc.creatorDa Fonseca, Luiz M.-
Data de aceite: dc.date.accessioned2025-08-21T18:05:54Z-
Data de disponibilização: dc.date.available2025-08-21T18:05:54Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2010-05-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/jf100233y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225844-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225844-
Descrição: dc.descriptionThe protective effect of gallic acid and its esters, methyl, propyl, and lauryl gallate, against 2,2'-azobis(2-amidinopropane)hydrochloride (AAPH)-induced hemolysis and depletion of intracellular glutathione (GSH) in erythrocytes was studied. The inhibition of hemolysis was dose-dependent, and the esters were significantly more effective than gallic acid. Gallic acid and its esters were compared with regard to their reactivity to free radicals, using the DPPH and AAPH/pyranine free-cell assays, and no significant difference was obtained. Gallic acid and its esters not only failed to inhibit the depletion of intracellular GSH in erythrocytes induced by AAPH but exacerbated it. Similarly, the oxidation of GSH by AAPH or horseradish peroxidase/H 2O2 in cell-free systems was exacerbated by gallic acid or gallates. This property could be involved in the recent findings on pro-apoptotic and pro-oxidant activities of gallates in tumor cells. We provide evidence that lipophilicity and not only radical scavenger potency is an important factor regarding the efficiency of antihemolytic substances. © 2010 American Chemical Society.-
Descrição: dc.descriptionDepartamento de Química Faculdade de Ciências UNESP, Bauru, SP, CEP 17033-360-
Descrição: dc.descriptionDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Unesp-Univ Estadual Paulista, Araraquara, São Paulo (SP)-
Descrição: dc.descriptionDepartamento de Química Orgânica Instituto de Química Unesp-Univ Estadual Paulista, Araraquara, São Paulo (SP)-
Descrição: dc.descriptionDepartamento de Química Faculdade de Ciências UNESP, Bauru, SP, CEP 17033-360-
Descrição: dc.descriptionDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Unesp-Univ Estadual Paulista, Araraquara, São Paulo (SP)-
Descrição: dc.descriptionDepartamento de Química Orgânica Instituto de Química Unesp-Univ Estadual Paulista, Araraquara, São Paulo (SP)-
Formato: dc.format5355-5362-
Idioma: dc.languageen-
Relação: dc.relationJournal of Agricultural and Food Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectErythrocytes-
Palavras-chave: dc.subjectGallates-
Palavras-chave: dc.subjectGallic acid-
Palavras-chave: dc.subjectGlutathione-
Palavras-chave: dc.subjectHemolysis-
Palavras-chave: dc.subjectPeroxyl radical-
Palavras-chave: dc.subjectPro-oxidant activity-
Título: dc.titleInhibitory effect of gallic acid and its esters on 2,2'-azobis(2- amidinopropane)hydrochloride (AAPH)-induced hemolysis and depletion of intracellular glutathione in erythrocytes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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