Imbalance of tumor suppression genes expression following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Autor(es): dc.creatorFracalossi, Ana Carolina Cuzzuol-
Autor(es): dc.creatorUatari, Silvia Akemi-
Autor(es): dc.creatorOshima, Celina Tizuko Fujiyama-
Autor(es): dc.creatorSalvadori, Daisy Maria Favero-
Data de aceite: dc.date.accessioned2025-08-21T17:07:14Z-
Data de disponibilização: dc.date.available2025-08-21T17:07:14Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2009-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225751-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225751-
Descrição: dc.descriptionThis study was undertaken to investigate, by immunohistochemistry, the expression of some tumor suppressor genes such as p16, p21 and Retinoblastoma (Rb) during 4-Nitroquinoline 1-oxide induced rat tongue carcinogenesis. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12 or 20 weeks. Ten animals were used as negative control. Neither histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, nor statistically significant differences (p>0.05) in expression of all the tumor suppressor genes were found when compared to the negative control. However, the levels of Rb were increased (p<0.05) in pre-neoplastic lesions at 12 weeks following carcinogen exposure. In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, p16 and Rb were expressed in some tumor cells. Taken together, the results support the belief that the expression of Rb is closely event-related to malignant transformation and conversion of the oral mucosa, being a reliable biomarker linked to oral cancer pathogenesis.-
Descrição: dc.descriptionDepartment of Pathology Federal University of Sao Paulo UNIFESP, SP-
Descrição: dc.descriptionDepartment of Biosciences Federal University of Sao Paulo UNIFESP, SP-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Sao Paulo State University UNESP, SP-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Sao Paulo State University UNESP, SP-
Formato: dc.format937-942-
Idioma: dc.languageen-
Relação: dc.relationIn Vivo-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject4-nitroquinoline 1-oxide-
Palavras-chave: dc.subjectMalignant transformation-
Palavras-chave: dc.subjectOral squamous cell carcinoma-
Palavras-chave: dc.subjectP16-
Palavras-chave: dc.subjectp21-
Palavras-chave: dc.subjectRat tongue mucosa-
Palavras-chave: dc.subjectRb-
Título: dc.titleImbalance of tumor suppression genes expression following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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