Reversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual do Centro-Oeste-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMainardes, Rubiana M.-
Autor(es): dc.creatorGremião, Maria Palmira D.-
Data de aceite: dc.date.accessioned2025-08-21T16:41:45Z-
Data de disponibilização: dc.date.available2025-08-21T16:41:45Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2009-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4067/S0716-97602009000300010-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225722-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225722-
Descrição: dc.descriptionThe development and validation of a simple and accurate method based on HPLC with ultraviolet detection for the quantification of zidovudine in rat plasma and its application to a pharmacokinetic study following a single intranasal dose zidovudine is described. Zidovudine was extracted from the plasma using a single-step deproteinization. Chromatographic separation of zidovudine from interfering components was achieved with a C-18 reverse phase column, a mobile phase consisting of a mixture of sodium acetate buffer (55mM) with pH adjusted to 7.0 and acetonitrile (91: 9 v/v) and UV detection set at 265 nm. The method was linear from 100 to 10000 ng.mL-1 (r2 ≥ 0.9995), and zidovudine had a mean recovery from plasma of 92.8%. The coefficient of variation of inter-day and intra-day quality control samples was less than 15%. After a single intranasal dose of zidovudine administered to rats, pharmacokinetic parameters (AUC0-24, Cmax, t max, t1/2) were determined. The proposed method was found to be simple, specific, accurate, and precise and could be applied to the quantitative analysis of clinical pharmacokinetic studies of zidovudine in rats.-
Descrição: dc.descriptionDepartamento de Farmácia Universidade Estadual do Centro-Oeste, Rua Simeão Camargo Varela de Sá n. 03, Guarapuava - PR 85040-080-
Descrição: dc.descriptionDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho/UNESP, Araraquara-SP-
Descrição: dc.descriptionDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho/UNESP, Araraquara-SP-
Formato: dc.format357-364-
Idioma: dc.languageen-
Relação: dc.relationBiological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAZT-
Palavras-chave: dc.subjectIntranasal delivery-
Palavras-chave: dc.subjectPharmacokinetics-
Palavras-chave: dc.subjectRP-HPLC-
Palavras-chave: dc.subjectValidation-
Título: dc.titleReversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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