No evidence of pathological autoimmunity following Mycobacterium leprae heat-shock protein 65-DNA vaccination in mice

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorNational Institute of Science and Technology - INCT-
Autor(es): dc.creatorLima, D. S.-
Autor(es): dc.creatorZárate-Bladés, C. R.-
Autor(es): dc.creatorSouza, P. R.M.-
Autor(es): dc.creatorTrombone, A. P.-
Autor(es): dc.creatorSantos, R. R.-
Autor(es): dc.creatorBrandão, I. T.-
Autor(es): dc.creatorMasson, A. P.-
Autor(es): dc.creatorBonato, V. L.-
Autor(es): dc.creatorCoelho-Castelo, A. A.M.-
Autor(es): dc.creatorSartori, A.-
Autor(es): dc.creatorVendramini, M.-
Autor(es): dc.creatorSoares, E. G.-
Autor(es): dc.creatorBenvenutti, L. A.-
Autor(es): dc.creatorSilva, C. L.-
Autor(es): dc.creatorCoelho, Verônica-
Data de aceite: dc.date.accessioned2025-08-21T23:45:52Z-
Data de disponibilização: dc.date.available2025-08-21T23:45:52Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2009-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/1721727x0900700204-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225607-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225607-
Descrição: dc.descriptionHeat-shock proteins (HSPs) are currently one of the most promising targets for the development of immunotherapy against tumours and autoimmune disorders. This protein family has the capacity to activate or modulate the function of different immune system cells. They induce the activation of monocytes, macrophages and dendritic cells, and contribute to cross-priming, an important mechanism of presentation of exogenous antigen in the context of MHC class I molecules. These various immunological properties of HSP have encouraged their use in several clinical trials. Nevertheless, an important issue regarding these proteins is whether the high homology among HSPs across different species may trigger the breakdown of immune tolerance and induce autoimmune diseases. We have developed a DNA vaccine codifying the Mycobacterium leprae Hsp65 (DNAhsp65), which showed to be highly immunogenic and protective against experimental tuberculosis. Here, we address the question of whether DNAhsp65 immunization could induce pathological autoimmunity in mice. Our results show that DNAhsp65 vaccination induced antibodies that can recognize the human Hsp60 but did not induce harmful effects in 16 different organs analysed by histopathology up to 210 days after vaccination. We also showed that anti-DNA antibodies were not elicited after DNA vaccination. The results are important for the development of both HSP and DNA-based immunomodulatory agents. Copyright © by BIOLIFE, s.a.s.-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology Medicine School of Ribeirão Preto University of São Paulo, São Paulo-
Descrição: dc.descriptionDepartment of Clinical Analyses Faculty of Pharmaceutical Sciences São Paulo State University, Araraquara, São Paulo-
Descrição: dc.descriptionDepartment of Microbiology and Immunology Biosciences Institute São Paulo State University, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Pathology University of São Paulo Medical School, São Paulo-
Descrição: dc.descriptionDepartment of Pathology School of Medicine of Ribeirão Preto University of São Paulo, Ribeirão Preto, São Paulo-
Descrição: dc.descriptionHeart Institute (InCor) University of São Paulo Medical School, São Paulo-
Descrição: dc.descriptionInstitute for Investigation in Immunology National Institute of Science and Technology - INCT, São Paulo-
Descrição: dc.descriptionInstituto do Coração Laboratório de Imunologia Universidade de São Paulo, Av Dr Eneas de Carvalho Aguiar, 44 bloco II, 9 andar, Cerqueira César, São Paulo - SP 05403-001-
Descrição: dc.descriptionDepartment of Clinical Analyses Faculty of Pharmaceutical Sciences São Paulo State University, Araraquara, São Paulo-
Descrição: dc.descriptionDepartment of Microbiology and Immunology Biosciences Institute São Paulo State University, Botucatu, São Paulo-
Formato: dc.format77-85-
Idioma: dc.languageen-
Relação: dc.relationEuropean Journal of Inflammation-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutoantibodies-
Palavras-chave: dc.subjectAutoimmunity-
Palavras-chave: dc.subjectDNA vaccine-
Palavras-chave: dc.subjectHeat-shock protein-
Título: dc.titleNo evidence of pathological autoimmunity following Mycobacterium leprae heat-shock protein 65-DNA vaccination in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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