Immunohistochemical expression of B and T-lymphocytes and TGF-β in experimentally transplanted canine venereal tumor

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTrompieri-Silveira, Ana Carolina-
Autor(es): dc.creatorGerardi, Daniel-
Autor(es): dc.creatorMouro, Juliana Vitti-
Autor(es): dc.creatorCosta, Mirela Tinucci-
Autor(es): dc.creatorAlessi, Antonio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T18:01:04Z-
Data de disponibilização: dc.date.available2025-08-21T18:01:04Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2009-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s0103-84782009005000025-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225594-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225594-
Descrição: dc.descriptionThe tumor/host relationship may have a determining role in the progression or remission of a tumor. Greater infiltration of leukocytes into tumors has been associated with a better prognosis, although controversy regarding whether these cells have a central role in antitumor immunity still exists. Canine transmissible venereal tumor (TVT) is an experimentally transplantable type of tumor that has been used as an experimental model for the tumor/host relationship. The aim of this study was to evaluate the infiltration of T-lymphocytes (CD3, CD4, CD8) and B lymphocytes (CD79-α) and the expression of the cytokine TGF-β in TVT, by means of immunohistochemistry (ABC method). The experimental tumors were composed of puppies that developed TVT after transplantation, in the progression (n=8) (Group 1a), latency (n=8) (Group 1b) and regression (n=8) (Group 1c) phases of the tumor. CD3+T-lymphocytes predominated in the progression and regression phases, in relation to the latency phase. CD4+and 1CD8+ T-lymphocytes were predominant in the progression phase, and with lower expression in the regression phase. The greatest quantities of B-lymphocytes were in the regression phase, with restricted expression in the progression phase. TGF-β was expressed equally in the phases of the transplanted TVT.-
Descrição: dc.descriptionDepartamento de Patologia Veterinária Universidade Estadual Paulista (UNESP), Via de acesso Professor Paulo Donato Castellani, s/n, 14884-900, Jaboticabal, SP-
Descrição: dc.descriptionDepartamento de Clínica e Cirurgia Veterinária UNESP, Jaboticabal, SP-
Descrição: dc.descriptionDepartamento de Patologia Veterinária Universidade Estadual Paulista (UNESP), Via de acesso Professor Paulo Donato Castellani, s/n, 14884-900, Jaboticabal, SP-
Descrição: dc.descriptionDepartamento de Clínica e Cirurgia Veterinária UNESP, Jaboticabal, SP-
Formato: dc.format1148-1154-
Idioma: dc.languagept_BR-
Relação: dc.relationCiencia Rural-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDog-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectLymphocytes-
Palavras-chave: dc.subjectTVT-
Título: dc.titleImmunohistochemical expression of B and T-lymphocytes and TGF-β in experimentally transplanted canine venereal tumor-
Título: dc.titleExpressão imunoistoquímica de linfócitos T e B e do TGF-β no tumor venéreo transmissível canino experimentalmente transplantado-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.