Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBrondani, Juliana T.-
Autor(es): dc.creatorLuna, Stelio P.L.-
Autor(es): dc.creatorMarcello, Gracy C.G.-
Autor(es): dc.creatorPadovani, Carlos R.-
Data de aceite: dc.date.accessioned2025-08-21T20:05:44Z-
Data de disponibilização: dc.date.available2025-08-21T20:05:44Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2009-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jfms.2008.12.003-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225471-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225471-
Descrição: dc.descriptionA randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5 mg/kg PO (V), tramadol 2 mg/kg SC (T), their association (VT) or placebo (P) in 40 adult female cats (3.0 ± 0.32 kg; 1.8 ± 0.7 years) distributed in groups of 10. Platelet aggregation and bleeding time were measured before and 52 h after ovariohysterectomy. Serum urea, creatinine, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase concentrations were measured before and 7 days postoperatively. The occurrence of vomiting, frequency and consistency of feces, and behavior were observed for 7 days postoperatively. Morphine (0.5 mg/kg, IM) was used as rescue analgesic. Laboratory variables did not change. Vomiting was observed only after morphine administration. Mild euphoria was observed in T and VT. The perioperative use of vedaprofen and/or tramadol did not modify the hemostatic, biochemical and gastrointestinal function in cats. © 2009 ESFM and AAFP.-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Biostatistics Institute of Biosciences São Paulo State University, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Biostatistics Institute of Biosciences São Paulo State University, Botucatu, São Paulo-
Formato: dc.format503-509-
Idioma: dc.languageen-
Relação: dc.relationJournal of Feline Medicine and Surgery-
???dc.source???: dc.sourceScopus-
Título: dc.titlePerioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats-
Tipo de arquivo: dc.typelivro digital-
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