Gene mutations in esophageal mucosa of chagas disease patients

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorManoel-Caetano, Fernanda DA Silva-
Autor(es): dc.creatorSilveira, Aparecida F. P.-
Autor(es): dc.creatorSilva, Ana Elizabete-
Data de aceite: dc.date.accessioned2025-08-21T18:35:04Z-
Data de disponibilização: dc.date.available2025-08-21T18:35:04Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2009-04-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225457-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225457-
Descrição: dc.descriptionBackground: Chagas disease patients with longstanding megaesophagus have a significantly increased risk for esophageal carcinoma. Materials and Methods: PCR- SSCP analysis and DNA sequencing of esophageal mucosa from Chagas disease patients (with or without megaesophagus) in the exons of the TPS3, CDKN2A and FHIT genes were performed. Results: SSCP analysis showed a mobility shift in 2/20 patients with grade TV megaesophagus (CDKN2A exon 1 and FHIT exon 7) and in 1/10 patients without megaesophagus (TP53 exons 5 and 8). However, DNA sequencing indicated a silent mutation in exon 7 of the FHIT gene (GCT → GCC) in codon 88 in only one case of megaesophagus. Conclusion: Gene mutations are rare events in the exons investigated in esophageal mucosa of Chagas disease patients and further investigations are important to clarify the possible involvement of this silent mutation in exon 7 (FHIT gene) in the advanced grades of megaesophagus and esophageal carcinogenesis.-
Descrição: dc.descriptionDepartment of Biology UNESP São Paulo State University, São José do Rio Preto, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Departamento de Biologia, Rua Cristóvão Colombo, 2265, CEP: 15054-000, São José do Rio Preto, SP-
Descrição: dc.descriptionDepartment of Biology UNESP São Paulo State University, São José do Rio Preto, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Departamento de Biologia, Rua Cristóvão Colombo, 2265, CEP: 15054-000, São José do Rio Preto, SP-
Formato: dc.format1243-1248-
Idioma: dc.languageen-
Relação: dc.relationAnticancer Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCdkn2a gene-
Palavras-chave: dc.subjectChagas disease-
Palavras-chave: dc.subjectDna sequencing-
Palavras-chave: dc.subjectFhitgene-
Palavras-chave: dc.subjectMegaesophagus, gene mutation-
Palavras-chave: dc.subjectSingle nucleotide polymorphism (snp)-
Palavras-chave: dc.subjectTp53 gene-
Título: dc.titleGene mutations in esophageal mucosa of chagas disease patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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