Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorRibeiro, Henrique Barbosa-
Autor(es): dc.creatorOkoshi, Marina Politi-
Autor(es): dc.creatorMatsubara, Beatriz Bojikian-
Autor(es): dc.creatorGonçalves, Giancarlo-
Autor(es): dc.creatorBarros, Reginaldo-
Autor(es): dc.creatorCicogna, Antonio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T20:15:11Z-
Data de disponibilização: dc.date.available2025-08-21T20:15:11Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2004-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1536/jhj.45.647-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225451-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225451-
Descrição: dc.descriptionThere is still controversy about the relation between changes in myocardial contractile function and global left ventricular (LV) performance during stable concentric hypertrophy. To clarify this, we analyzed LV function in vivo and myocardial mechanics in vitro in rats with pressure overload-induced cardiac hypertrophy. Male Wistar rats (70 g) underwent ascending aortic stenosis for 8 weeks (group AAS, n = 9). LV performance was assessed by transthoracic echocardiography under anesthesia. Myocardial function was studied in isolated papillary muscle preparations during isometric contraction. The data were compared with age- and sex-matched sham-operated rats (group C, n = 9). LV weight-to-body weight ratio (C: 2.13 ± 0.14 mg/g; AAS: 3.24 ± 0.44 mg/g), LV relative wall thickness (C: 0.18 ± 0.02; AAS: 0.33 ± 0.09), and LV fractional shortening (C: 54 ± 5%; AAS: 70 ± 8%) were increased in group AAS (P < 0.05). Echocardiographic analysis also indicated a significant association (r = 0.74; P < 0.001) between the percent fractional shortening index and LV relative wall thickness. The performance of AAS isolated muscle revealed that active tension (C: 6.6 ± 1.7 g/mm2; AAS: 6.5 ± 1.5 g/mm2) and maximum rate of tension development (C: 69 ± 21 g/mm2/s; AAS: 69 ± 18 g/mm2/s) were not significantly different from group C (P > 0.05). In conclusion, compensated pressureoverload myocardial hypertrophy is associated with preserved myocardial function and increased ventricular performance. The improved LV function might be due to the ventricular remodeling characterized by an increased relative wall thickness. Copyright © 2004 by the Japanese Heart Journal.-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School State University Julio de Mesquita Filho, Botucatu, Sao Paulo-
Descrição: dc.descriptionDepartamento de Clínica Medica Faculdade de Medicina de Botucatu UNESP, Rubiao Junior S/N, 618-000 Botucatu, Sao Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School State University Julio de Mesquita Filho, Botucatu, Sao Paulo-
Descrição: dc.descriptionDepartamento de Clínica Medica Faculdade de Medicina de Botucatu UNESP, Rubiao Junior S/N, 618-000 Botucatu, Sao Paulo-
Formato: dc.format647-656-
Idioma: dc.languageen-
Relação: dc.relationJapanese Heart Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAortic stenosis-
Palavras-chave: dc.subjectCardiac function-
Palavras-chave: dc.subjectEchocardiography-
Palavras-chave: dc.subjectLeft ventricular hypertrophy-
Palavras-chave: dc.subjectPapillary muscle-
Título: dc.titleImproved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.