p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHospital Sírio Libanês-
Autor(es): dc.contributorFAMERP - Medical School-
Autor(es): dc.creatorBellini, Marilanda Ferreira-
Autor(es): dc.creatorLeite, Kátia Ramos Moreira-
Autor(es): dc.creatorCury, Patrícia Maluf-
Autor(es): dc.creatorSilva, Ana Elizabete-
Data de aceite: dc.date.accessioned2025-08-21T17:37:18Z-
Data de disponibilização: dc.date.available2025-08-21T17:37:18Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2008-11-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225387-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225387-
Descrição: dc.descriptionBackground: Models have suggested esophageal carcinogenesis can result from the alteration of sequences, leading to esophagitis, atrophy, dysplasia, carcinoma in situ and invasive carcinoma. While numerous genetic alterations have been reported in esophageal carcinogenesis, studies of benign lesions with precancerous potential are scarce. Materials and Methods: Immunohistochemistry was performed for p53, p16 and Fhit proteins in the esophageal mucosa from patients with Chagas disease (CD), chagasic megaesophagus (CM), chronic esophagitis (CE), esophageal squamous cell carcinoma (ESCC) and in normal mucosa (NM). Results: The proportion of p53-positive cases increased progressively according to the severity of the pathology CD (7.7%), CM (26.1%), CE (52.2%) and ESCC (100%). However, p16 and Fhit did not show any statistically significant differences among the groups. Conclusion: p53 overexpression is involved in the initial steps of esophageal carcinogenesis, supporting further evaluation of its utility as a marker in precursor lesions, conversely, losses of Fhit and p16 expression may not be significant.-
Descrição: dc.descriptionDepartment of Biology UNESP Säo Paulo State University, SP-
Descrição: dc.descriptionLaboratory of Surgery and Molecular Pathology Hospital Sírio Libanês, São Paulo, SP-
Descrição: dc.descriptionDepartment of Pathology FAMERP - Medical School, São José do Rio Preto, SP-
Descrição: dc.descriptionIBILCE UNESP Departamento de Biologia, Rua Cristóvão Colombo, 2265, São José do Rio Preto, SP - CEP. 15054-000-
Descrição: dc.descriptionDepartment of Biology UNESP Säo Paulo State University, SP-
Descrição: dc.descriptionIBILCE UNESP Departamento de Biologia, Rua Cristóvão Colombo, 2265, São José do Rio Preto, SP - CEP. 15054-000-
Formato: dc.format3793-3799-
Idioma: dc.languageen-
Relação: dc.relationAnticancer Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEsophageal carcinoma-
Palavras-chave: dc.subjectEsophagitis-
Palavras-chave: dc.subjectFhit protein-
Palavras-chave: dc.subjectMegaesophagus-
Palavras-chave: dc.subjectp16-
Palavras-chave: dc.subjectp53-
Título: dc.titlep53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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