In vivo effects of Bothrops jararaca venom on metabolic profile and on muscle protein metabolism in rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSchool of Medicine of São José do Rio Preto-
Autor(es): dc.creatorGonçalves, Dawit A. P.-
Autor(es): dc.creatorSilva, Érico V. C. M.-
Autor(es): dc.creatorGraça, Flávia A.-
Autor(es): dc.creatorLira, Eduardo C.-
Autor(es): dc.creatorZanon, Neusa M.-
Autor(es): dc.creatorMendes, Glória E.-
Autor(es): dc.creatorBurdmann, Emmanuel A.-
Autor(es): dc.creatorMigliorini, Renato H.-
Autor(es): dc.creatorKettelhut, Isis C.-
Autor(es): dc.creatorNavegantes, Luiz C. C.-
Data de aceite: dc.date.accessioned2025-08-21T19:48:44Z-
Data de disponibilização: dc.date.available2025-08-21T19:48:44Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2008-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4269/ajtmh.2008.79.771-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225328-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225328-
Descrição: dc.descriptionThis study investigated the in vivo effects of the Bothrops jararaca venom (BjV) on general metabolic profile and, specifically, on muscle protein metabolism in rats. The crude venom (0.4 mg/kg body weight, IV) was infused in awake rats, and plasma activity of enzymes and metabolites levels were determined after 1, 2, 3, and 4 hours. BjV increased urea, lactate, and activities of creatine kinase, lactate dehydrogenase, and aspartate aminotransferase after 4 hours. The content of liver glycogen was reduced by BjV. Protein metabolism was evaluated by means of microdialysis technique and in isolated muscles. BjV induced increase in the muscle interstitial-arterial tyrosine concentration difference, indicating a high protein catabolism. The myotoxicity induced by this venom is associated with reduction of protein synthesis and increase in rates of overall proteolysis, which was accompanied by activation of lysosomal and ubiquitin-proteasome systems without changes in protein levels of cathepsins and ubiquitin-protein conjugates. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.-
Descrição: dc.descriptionDepartment of Physiology School of Medicine of Ribeirão Preto USP, 14049-900, Ribeirão Preto, SP-
Descrição: dc.descriptionDepartment of Ophthalmology Otorhinolaryngology and Head and Neck Surgery School of Medicine of Botucatu UNESP, 18618-000, Botucatu, SP-
Descrição: dc.descriptionDepartment of Molecular Biology Division of Nephrology School of Medicine of São José do Rio Preto, 15090-000, São José do Rio Preto, SP-
Descrição: dc.descriptionDepartment of Physiology and Biochemistry and Immunology School of Medicine of Ribeirão Preto USP, 14049-900, Ribeirão Preto, SP-
Descrição: dc.descriptionDepartment of Ophthalmology Otorhinolaryngology and Head and Neck Surgery School of Medicine of Botucatu UNESP, 18618-000, Botucatu, SP-
Formato: dc.format771-778-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Tropical Medicine and Hygiene-
???dc.source???: dc.sourceScopus-
Título: dc.titleIn vivo effects of Bothrops jararaca venom on metabolic profile and on muscle protein metabolism in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.