Maximum inhibitory dilution of mouthwashes containing chlorhexidine and polyhexamethylene biguanide against salivary Staphylococcus aureus

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorNascimento, Andresa Piacezzi-
Autor(es): dc.creatorTanomaru, Juliane Maria Guerreiro-
Autor(es): dc.creatorMatoba Jr., Fumio-
Autor(es): dc.creatorWatanabe, Evandro-
Autor(es): dc.creatorTanomaru-Filho, Mario-
Autor(es): dc.creatorIto, Izabel Yoko-
Data de aceite: dc.date.accessioned2025-08-21T22:50:02Z-
Data de disponibilização: dc.date.available2025-08-21T22:50:02Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2008-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1678-77572008000500006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225309-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225309-
Descrição: dc.descriptionObjective: The aim of the present study was to determine the in vitro maximum inhibitory dilution (MID) of two chlorhexidine-based oral mouthwashes (CHX): Noplak®, Periogard®, and one polyhexamethylene biguanide-based mouthwash (PHMB): Sanifill Premium® against 28 field Staphylococcus aureus strains using the agar dilution method. Materials and Methods: For each product, decimal dilutions ranging from 1/10 to 1/655,360 were prepared in distilled water and added to Mueller Hinton Agar culture medium. After homogenization, the culture medium was poured onto Petri dishes. Strains were inoculated using a Steers multipoint inoculator and dishes were incubated at 37°C for 24hours. For reading, MID was considered as the maximum dilution of the mouthwash still capable of inhibiting microbial growth. Results: Sanifill Premium® inhibited the growth of all strains at 1/40 dilution and of 1 strain at 1/80 dilution. Noplak® inhibited the growth of 23 strains at 1/640 dilution and of all 28 strains at 1/320 dilution. Periogard® showed inhibited growth of 7 strains at 1/640 dilution and of all 28 strains at 1/320 dilution. Data were submitted to Kruskal-Wallis statistical test, showing significant differences between the mouthwashes evaluated (p<0.05). No significant difference was found between Noplak® and Periogard® p>0.05). Sanifill Premium® was the least effective (p<0.05). Conclusion: It was concluded that CHX-based mouthwashes present better antimicrobial activity against S. Aureus than the PHMB-based mouthwash.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo USP, Ribeirão Preto, SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Araraquara School of Dentistry São Paulo State University, Araraquara, SP-
Descrição: dc.descriptionRibeirão Preto School of Dentistry University of São Paulo USP, Ribeirão Preto, SP-
Descrição: dc.descriptionDepartment of Microbiology School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo USP, Ribeirão Preto, SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Araraquara School of Dentistry São Paulo State University, Araraquara, SP-
Formato: dc.format336-339-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Oral Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnti-infective agents-
Palavras-chave: dc.subjectBacteria-
Palavras-chave: dc.subjectChlorhexidine-
Título: dc.titleMaximum inhibitory dilution of mouthwashes containing chlorhexidine and polyhexamethylene biguanide against salivary Staphylococcus aureus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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