Production OF Trichophyton mentagrophytes antigens and their characterization in mice

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorVenturini, J.-
Autor(es): dc.creatorRossi-Ferreira, R.-
Autor(es): dc.creatorArruda, M. S.P.-
Data de aceite: dc.date.accessioned2025-08-21T23:16:13Z-
Data de disponibilização: dc.date.available2025-08-21T23:16:13Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2008-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000300003-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225270-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225270-
Descrição: dc.descriptionThe participation of dermatophytic antigens in the host-parasite balance is still poorly understood. One of the difficulties encountered by researchers is the lack of dominant and specific antigens that can be used in such studies. In order to contribute to a better understanding of this aspect of infection, the present study identifies antigen fractions obtained from exoantigen and cytoplasmic extracts of Trichophyton mentagrophytes. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) revealed the presence of 13 proteins in the exoantigen extract, whose molecular weight ranged from 12.5 to 90 kDa. The cytoplasmic extract contained 18 protein fractions ranging from 11 to 110 kDa. Immunoblotting showed the presence of immunodominant antigens against IgG, IgM and IgA antibodies. This affinity was observed in three proteins of the exoantigen extract and in three proteins of the cytoplasmic extract, with respective molecular weights of 33, 39 and 59, and 40, 55 and 82 kDa. These results are promising, especially when considering that these extracts contain antigenically distinct protein fractions which, once determined, may contribute to a better understanding of dermatophytoses, and may thus help in the development of alternative strategies for the diagnosis and treatment of this condition.-
Descrição: dc.descriptionDepartment of Biological Science School of Science São Paulo State University UNESP, Bauru, São Paulo State-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School São Paulo State University UNESP, Botucatu, São Paulo State-
Descrição: dc.descriptionDepartamento de Ciências Biológicas Faculdade de Ciências Universidade Estadual Paulista UNESP, Av. Eng. Luiz Edmundo Carrijo Coube, s/n, Bauru, SP, 17033-360-
Descrição: dc.descriptionDepartment of Biological Science School of Science São Paulo State University UNESP, Bauru, São Paulo State-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School São Paulo State University UNESP, Botucatu, São Paulo State-
Descrição: dc.descriptionDepartamento de Ciências Biológicas Faculdade de Ciências Universidade Estadual Paulista UNESP, Av. Eng. Luiz Edmundo Carrijo Coube, s/n, Bauru, SP, 17033-360-
Formato: dc.format409-422-
Idioma: dc.languageen-
Relação: dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntigens-
Palavras-chave: dc.subjectTrichophyton mentagrophytes-
Título: dc.titleProduction OF Trichophyton mentagrophytes antigens and their characterization in mice-
Tipo de arquivo: dc.typelivro digital-
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