Sedative and cardiorespiratory effects of acepromazine or atropine given before dexmedetomidine in dogs

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAlvaides, R. K.-
Autor(es): dc.creatorTeixeira Neto, F. J.-
Autor(es): dc.creatorAguiar, A. J.A.-
Autor(es): dc.creatorCampagnol, D.-
Autor(es): dc.creatorSteagall, P. V.M.-
Data de aceite: dc.date.accessioned2025-08-21T20:02:44Z-
Data de disponibilização: dc.date.available2025-08-21T20:02:44Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2008-06-28-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1136/vr.162.26.852-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225229-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225229-
Descrição: dc.descriptionTo test the hypothesis that acepromazine could potentiate the sedative actions and attenuate the pressor response induced by dexmedetomidine, the effects of acepromazine or atropine were compared in six healthy adult dogs treated with this α2-agonist. In a randomised block design, the dogs received intravenous doses of either physiological saline, 0-05 mg/kg acepromazine or 0-04 mg/kg atropine, 15 minutes before an intravenous dose of 5 ug/kg dexmedetomidine. The dogs' heart rate was reduced by 50 to 63 per cent from baseline and their mean arterial blood pressure was increased transiently from baseline for 20 minutes after the dexmedetomidine. Atropine prevented the α2-agonist-induced bradycardia and increased the severity and duration of the hypertension, but acepromazine did not substantially modify the cardiovascular effects of the α2-agonist, except for a slight reduction in the magnitude and duration of its pressor effects. The dexmedetomidine induced moderate to intense sedation in all the treatments, but the dogs' sedation scores did not differ among treatments. The combination of acepromazine with dexmedetomidine had no obvious advantages in comparison with dexmedetomidine alone, but the administration of atropine before dexmedetomidine is contraindicated because of a severe hypertensive response.-
Descrição: dc.descriptionDepartamento de Cirurgia e Anestesiologia Veterinária Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista, Botucatu, São Paulo, CEP 18618-000-
Descrição: dc.descriptionDepartamento de Cirurgia e Anestesiologia Veterinária Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista, Botucatu, São Paulo, CEP 18618-000-
Formato: dc.format852-856-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Record-
???dc.source???: dc.sourceScopus-
Título: dc.titleSedative and cardiorespiratory effects of acepromazine or atropine given before dexmedetomidine in dogs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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