Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUNOESTE-
Autor(es): dc.contributorCESUMAR-
Autor(es): dc.creatorSangiorgio, Fabíola-
Autor(es): dc.creatorSakate, M.-
Autor(es): dc.creatorNogueira, R. M.B.-
Autor(es): dc.creatorTostes, R. A.-
Data de aceite: dc.date.accessioned2025-08-21T17:56:45Z-
Data de disponibilização: dc.date.available2025-08-21T17:56:45Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2008-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000100007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225098-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225098-
Descrição: dc.descriptionThe present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.-
Descrição: dc.descriptionDepartment of Small Animal Medical Clinic and Toxicology School of Veterinary Medicine and Animal Husbrandy São Paulo State University - UNESP, Botucatu, São Paulo State-
Descrição: dc.descriptionDepartment of Small Animal Medical Clinic University of Western São Paulo UNOESTE, Presidente Prudente, São Paulo State-
Descrição: dc.descriptionMaringá University Center CESUMAR, Maringá, Paraná State-
Descrição: dc.descriptionDepartment of Small Animal Medical Clinic and Toxicology School of Veterinary Medicine and Animal Husbrandy São Paulo State University - UNESP, Botucatu, São Paulo State-
Formato: dc.format82-99-
Idioma: dc.languageen-
Relação: dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases-
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Palavras-chave: dc.subjectCrotalus durissus terrificus-
Palavras-chave: dc.subjectDogs-
Palavras-chave: dc.subjectHistopathology-
Palavras-chave: dc.subjectIntoxication-
Palavras-chave: dc.subjectTreatment-
Título: dc.titleHistopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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