Exposure time and ventricular remodeling induced by tobacco smoke exposure in rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCastardeli, Edson-
Autor(es): dc.creatorDuarte, Daniella R.-
Autor(es): dc.creatorMinicucci, Marcos F.-
Autor(es): dc.creatorAzevedo, Paula S.-
Autor(es): dc.creatorMatsubara, Beatriz B.-
Autor(es): dc.creatorMatsubara, Luiz S.-
Autor(es): dc.creatorCampana, Álvaro O.-
Autor(es): dc.creatorPaiva, Sergio A. R.-
Autor(es): dc.creatorZornoff, Leonardo A. M.-
Data de aceite: dc.date.accessioned2025-08-21T21:23:07Z-
Data de disponibilização: dc.date.available2025-08-21T21:23:07Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2008-03-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/225091-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/225091-
Descrição: dc.descriptionBackground: We investigated the effects of length of exposure to tobacco smoke on the cardiac remodeling process induced by exposure to cigarette smoke in rats. Material/Methods: Rats were separated into 4 groups: nonsmoking (NS)2 (n=25; control animals not exposed to tobacco smoke for 2 months), smoking (S)2 (n=22; rats exposed to smoke from 40 cigarettes/d for 2 months), NS6 (n=18; control animals not exposed to tobacco smoke for 6 months), and S6 (n=25; rats exposed to smoke from 40 cigarettes/d for 6 months). All animals underwent echocardiographic, isolated heart, and morphometric studies. Data were analyzed with a 2-way analysis of variance. Results: No interaction among the variables was found; this suggests that length of exposure to tobacco smoke did not influence the effects of exposure to smoke. Values for left ventricular diastolic diameter/body weight and left atrium/body weight were higher (p=0.023 and p=0.001, respectively) in smoking (S2 and S6) than in nonsmoking animals (NS2 and NS6). Left ventricular mass index was higher (p=0.048) in smoking than in nonsmoking animals. In the isovolumetrically beating ventricle, peak systolic pressure was higher (p=0.034) in smoking than in nonsmoking animals. Significantly higher values were found for left ventricular weight (p=0.017) and right ventricular weight (p=0.001) adjusted for body weight in smoking as opposed to nonsmoking animals. Systolic pressure was higher (p=0.001) in smoking (128±14 mm Hg) than in nonsmoking animals (112±11 mm Hg). Conclusions: Length of exposure to cigarette smoke did not influence cardiac remodeling caused by exposure to smoke in rats. © Med Sci Monit, 2008.-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School UNESP - São Paulo State University, Botucatu-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu, Rubião Júnior s/n, Botucatu, SP, CEP: 18618-000-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School UNESP - São Paulo State University, Botucatu-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu, Rubião Júnior s/n, Botucatu, SP, CEP: 18618-000-
Idioma: dc.languageen-
Relação: dc.relationMedical Science Monitor-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFibrosis-
Palavras-chave: dc.subjectVentricular dilatation-
Palavras-chave: dc.subjectVentricular function-
Título: dc.titleExposure time and ventricular remodeling induced by tobacco smoke exposure in rats-
Tipo de arquivo: dc.typelivro digital-
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