Continuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and/or medetomidine pre-treated with methotrimeprazine and buprenorphine

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSilva, Fernando Do Carmo-
Autor(es): dc.creatorHatschbach, Eduardo-
Autor(es): dc.creatorLima, Alfredo Feio Da Maia-
Autor(es): dc.creatorDe Carvalho, Yuri Karaccas-
Autor(es): dc.creatorMassone, Flavio-
Data de aceite: dc.date.accessioned2025-08-21T18:26:03Z-
Data de disponibilização: dc.date.available2025-08-21T18:26:03Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2007-07-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224936-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224936-
Descrição: dc.descriptionPurpose: To compare, by continuous infusion of ketamine or medetomidine combined to methotrimeprazine and buprenorphine, ketamine and midazolam, the degree of hypnosis, myorelaxation, anesthetic quality and surgical feasibility through evaluation of possible parametric alterations and recovery quality. Methods: 20 healthy adult females dogs, aged 3 to 5 years, body weight between 7 and 15 kg, were assigned randomly and homogenously to 2 groups of 10 animals each (n=10), group 1 (G1) and group 2 (G2), respectively. Animals of G1 were subjected to a pre-treatment with intravenous 1.0 mg/kg methotrimeprazine and or 3ì/kg. After 15 minutes, a 5.0 mg/kg ketamine and 0.2 mg/kg midazolam were intravenously injected. Immediately after induction, an anesthetic combination of 0.4 mg/kg/h midazolam, 20 mg/kg/h ketamine and 1.0 mg/kg/h xylazine, was continuously and intravenously administered for 30 minutes. The same techniques were used in G2 except for the substitution of xylazine for 30ìg/kg/h medetomidine. Results: In G1 there was a 1st and 2nd degree atrioventricular heart block, a longer recovery period and lower quality. In G2 a 1st degree atrioventricular heart block occurred but isolated and ephemeral. Conclusions: The continuous infusion method, besides reducing drugs utilization, prevented collateral effects allowing a more tranquil recovery with no excitations, both protocols permitted the surgical procedure (ovary-hysterectomy) bringing about a reduction in hypnosis and an accentuated myorelaxation. Xylazine and medetomidine showed a similar pharmacodynamic behavior but with different clinical aspects. The electrocardiographic alterations observed in G2 and in a lower degree in G1 must be well studied. Describers: dogs, ketamine, methotrimeprazine, medetomidine, midazolam and xylazine.-
Descrição: dc.descriptionExperimental Anesthesiology Faculty of Medicine UNESP, Botucatu, São Paulo-
Descrição: dc.descriptionFaculty of Veterinary Medicine and Zootechny Department of Surgery and Veterinary Anesthesiology UNESP, Botucatu, São Paulo-
Descrição: dc.descriptionExperimental Anesthesiology Faculty of Medicine UNESP, Botucatu, São Paulo-
Descrição: dc.descriptionFaculty of Veterinary Medicine and Zootechny Department of Surgery and Veterinary Anesthesiology UNESP, Botucatu, São Paulo-
Formato: dc.format271-277-
Idioma: dc.languageen-
Relação: dc.relationActa Cirurgica Brasileira-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDogs-
Palavras-chave: dc.subjectMedetomidine-
Palavras-chave: dc.subjectMethotrimeprazine-
Palavras-chave: dc.subjectMidazolam-
Palavras-chave: dc.subjectXylazine-
Título: dc.titleContinuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and/or medetomidine pre-treated with methotrimeprazine and buprenorphine-
Tipo de arquivo: dc.typeaula digital-
Aparece nas coleções:Repositório Institucional - Unesp

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