Renal function and histology after acute hemorrhage in rats under dexmedetomidine action

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMarangoni, Marco Aurelio-
Autor(es): dc.creatorHausch, Alex-
Autor(es): dc.creatorVianna, Pedro Thadeu Galvão-
Autor(es): dc.creatorBraz, José Reinaldo Cerqueira-
Autor(es): dc.creatorViero, Rosa Marlene-
Autor(es): dc.creatorCastiglia, Yara Marcondes Machado-
Data de aceite: dc.date.accessioned2025-08-21T22:45:56Z-
Data de disponibilização: dc.date.available2025-08-21T22:45:56Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2007-07-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224934-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224934-
Descrição: dc.descriptionPurpose: About 50 % of indications for dialysis in acute renal failure are related to problems originated during the perioperative period. Intraoperative hemodynamic changes lead to renal vasoconstriction and hypoperfusion. Previous studies have not defined the dexmedetomidine renal role in hemorrhage situations. This study evaluated the effect of dexmedetomidine on renal function and histology after acute hemorrhage in rats. Methods: Covered study with 20 Wistars rats, anesthetized with sodium pentobarbital, 50 mg. kg-1, intraperitoneal, randomized into 2 groups submitted to 30% volemia bleeding: DG - iv dexmedetomidine, 3 μg. kg-1 (10 min) and continuous infusion - 3 μg. kg-1. h-1; CG - pentobarbital. For renal clearance estimative, sodium p-aminohippurate and iothalamate were administered. Studied attributes: heart rate, mean arterial pressure, rectal temperature, hematocrit, iothalamate and p-aminohippurate clearance, filtration fraction, renal blood flow, renal vascular resistance, and histological evaluations of the kidneys. Results: DG showed smaller values of heart rate, mean arterial pressure, and renal vascular resistance, but iothalamate clearance and filtration fraction values were higher. There was similarity in p-aminohippurate clearance and renal blood flow. Both groups had histological changes ischemia-like, but dexmedetomidine determined higher tubular dilatation scores. Conclusion: In rats, after acute hemorrhage, dexmedetomidine determined better renal function, but higher tubular dilation scores.-
Descrição: dc.descriptionPostgraduate Program in Anesthesiology Medical School UNESP, Botucatu-
Descrição: dc.descriptionDepartment of Anesthesiology Medical School UNESP, Botucatu-
Descrição: dc.descriptionDepartment of Pathology Medical School UNESP, Botucatu-
Descrição: dc.descriptionDepartment of Anesthesiology Medical School UNESP, Distrito Rubião Junior, s/n, 18618-970 Botucatu - SP-
Descrição: dc.descriptionPostgraduate Program in Anesthesiology Medical School UNESP, Botucatu-
Descrição: dc.descriptionDepartment of Anesthesiology Medical School UNESP, Botucatu-
Descrição: dc.descriptionDepartment of Pathology Medical School UNESP, Botucatu-
Descrição: dc.descriptionDepartment of Anesthesiology Medical School UNESP, Distrito Rubião Junior, s/n, 18618-970 Botucatu - SP-
Formato: dc.format290-297-
Idioma: dc.languageen-
Relação: dc.relationActa Cirurgica Brasileira-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDexmedetomidine-
Palavras-chave: dc.subjectHypotension-
Palavras-chave: dc.subjectKidney-
Palavras-chave: dc.subjectPentobarbital-
Título: dc.titleRenal function and histology after acute hemorrhage in rats under dexmedetomidine action-
Tipo de arquivo: dc.typeaula digital-
Aparece nas coleções:Repositório Institucional - Unesp

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