Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal Fluminense University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorLima, Alfredo Feio Da Maia-
Autor(es): dc.creatorRahal, Sheila Canevese-
Autor(es): dc.creatorVolpi, Reinaldo Dos Santos-
Autor(es): dc.creatorGranjeiro, José Mauro-
Autor(es): dc.creatorTaga, Rumio-
Autor(es): dc.creatorCestari, Tania Maria-
Data de aceite: dc.date.accessioned2025-08-21T17:52:05Z-
Data de disponibilização: dc.date.available2025-08-21T17:52:05Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2007-07-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224933-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224933-
Descrição: dc.descriptionPurpose: To investigate the effect of bovine bone morphogenetic proteins (bBMPs) bound to hydroxyapatite plus collagen in the healing of unstable radius fractures. Methods: A transverse fracture was induced at the mid of the diaphysis in both radii on 15 Norfolk rabbits with average age of 5.5 months and 3.5kg. A mixture of bBMPs bound to thin powdered hydroxyapatite (bBMP-HA) and bovine collagen as agglutinant was applied to the right radius fracture site. The left radius fracture was considered control and no treatment was used. After 30, 60 and 90 days (5 rabbits/period) the rabbits were euthanized and the radii were collected for histological analysis. Results: The descriptive histological analysis revealed that repair was similar for both forelimbs. The histomorphometric analysis showed that the mean area of newly formed bone was 867442.16 mm2, 938743.00 mm2 and 779621.06 mm2 for the control forelimbs, and 841118.47 mm2, 788038.76mm2 and 618587.24 mm2 for the treated forelimbs at 30, 60 and 90 days, respectively. Thus the newly formed bone area was 12.17% larger in the forelimbs treated with bBMP-HA/collagen than in the control forelimbs (p<0.05, Tukey test) in the 60-day period after surgery. In both forelimbs the newly formed bone area increased throughout the experimental period until the complete fracture healing. Conclusion: Based on the result obtained here we concluded that bBMP-HA/collagen induced a lower but significant improvement in fracture consolidation.-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science Department of Veterinary Surgery and Anesthesiology UNESP, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Orthopedic Science Faculty of Medicine UNESP, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Cellular and Molecular Biology Biology Institute Federal Fluminense University, Rio de Janeiro-
Descrição: dc.descriptionDepartment of Histology and Embryology Faculty of Dentistry of Bauru São Paulo University (USP), Bauru, São Paulo-
Descrição: dc.descriptionSao Paulo State University (UNESP) Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science, Rubião Júnior, s/n, 18618-000 Botucatu - SP-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science Department of Veterinary Surgery and Anesthesiology UNESP, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Orthopedic Science Faculty of Medicine UNESP, Botucatu, São Paulo-
Descrição: dc.descriptionSao Paulo State University (UNESP) Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science, Rubião Júnior, s/n, 18618-000 Botucatu - SP-
Formato: dc.format259-264-
Idioma: dc.languageen-
Relação: dc.relationActa Cirurgica Brasileira-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBone morphogenetic proteins-
Palavras-chave: dc.subjectFracture healing-
Palavras-chave: dc.subjectRabbits-
Título: dc.titleEffect of bovine bone morphogenetic proteins on radius fracture healing in rabbits-
Tipo de arquivo: dc.typeaula digital-
Aparece nas coleções:Repositório Institucional - Unesp

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