Endocrine response to lactate infusion during pentobarbitone anaesthesia

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Camnbrrdge-
Autor(es): dc.creatorLuna, S. P.L.-
Autor(es): dc.creatorTaylor, P. M.-
Data de aceite: dc.date.accessioned2025-08-21T18:53:27Z-
Data de disponibilização: dc.date.available2025-08-21T18:53:27Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1996-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.1996.tb00290.x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224866-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224866-
Descrição: dc.descriptionLactic acid was infused iv in 6 Welsh ponies during pentobarbitone anaesthesia to investigate whether lactate triggers the pituitary-adrenal response to anaesthesia. Ponies were premedicated with acepromazine and anaesthesia was induced with pentobarbitone iv and maintained with pentobarbitone/oxygen for 2 h. Immediately after induction, 3% L(+) lactic acid infusion was started and adjusted to maintain plasma lactate concentration between 2 and 2.5 mmol/l. Cardiorespiratory function, temperature. PCV, plasma glucose, lactate, βendorphin, ACTH, cortisol and catecholamine concentrations were measured before, during and after anaesthesia. Hypothermia, reduced PCV, slight hypotension (minimum value 84 ± 6 mmHg 20 min after induction of anaesthesia), hyperoxia and marked bradypnoea developed during anaesthesia. No acidaemia occurred. Plasma glucose concentration increased at the end of anaesthesia. There were no changes in plasma ACTH, cortisol and catecholamine concentrations, but plasma & endorphin increased after induction until the end of anaesthesia. There was a correlation between plasma lactate and β-endorphin concentrations (P<0.001, r=0.63), which may suggest that lactate stimulates βendorphin release. Beta-endorphin was apparently secreted independently from ACTH and appears to be a sensitive marker of a stress response. © 1996 Wiley. All rights reserved.-
Descrição: dc.descriptionDepartment of veterinary Surgery mid Anaesthesiology Veterrrznry Medicine and Aninial Science University of São Paillo State (UNESP), Srlo Paulo, Botucntu, 18618-000-
Descrição: dc.descriptionDepartment of Clinical Veterinory Medicine University of Camnbrrdge, Mridinglev Road, Cambridge, CB3 OES-
Descrição: dc.descriptionDepartment of veterinary Surgery mid Anaesthesiology Veterrrznry Medicine and Aninial Science University of São Paillo State (UNESP), Srlo Paulo, Botucntu, 18618-000-
Formato: dc.format60-63-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Anaesthesia and Analgesia-
???dc.source???: dc.sourceScopus-
Título: dc.titleEndocrine response to lactate infusion during pentobarbitone anaesthesia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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