Influence of moderate physical training on the GH/IGF-1 axis in diabetic rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGomes, Ricardo José-
Autor(es): dc.creatorCaetano, F. H.-
Autor(es): dc.creatorMello, M. A.R.-
Autor(es): dc.creatorLuciano, E.-
Data de aceite: dc.date.accessioned2025-08-21T18:15:48Z-
Data de disponibilização: dc.date.available2025-08-21T18:15:48Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2006-10-26-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224821-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224821-
Descrição: dc.descriptionThe influence of moderate physical training on serum growth hormone (GH), insulin-like growth factor -1 (IGF-1) and binding protein (IGFBP-3) in experimental diabetic rats was investigated. Male Wistar rats were divided into 4 groups, sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Experimental diabetes was induced of Alloxan (35mg/b.w.) The training program consisted by swimming 5 days/week, 1 h/day, supporting a load of 2.5% b.w., during 6 weeks. Then, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, GH, IGF-1 and IGFBP-3. Samples of liver were used to evaluate glycogen, protein and DNA contents. The results were analyzed by ANOVA, and Bonferroni test and the significance level was set at 2.5%. Diabetes decreased serum GH, IGF-1, IGFBP-3 and liver glycogen stores in SD group. Physical training promoted increase in serum IGF-1 in both TC and TD groups (SC=82±15; TC=103±13; SD=77±16; TD=112±29 ng/ml) and liver glycogen store in TD group when compared to SD (SC=5.2±1.2; TC=6.2±1; SD=2±0.5; TD=5±1.8 mg/100mg). Therefore, physical training contributes to the increase in liver glycogen content and to rise of insulin-like growth factor level in diabetic rats. It was concluded that moderate physical training promotes important adaptations related to GH-IGF-1 axis in diabetic organisms.-
Descrição: dc.descriptionDept. of Physical Education State University of São Paulo (UNESP), Rio Claro-SP-
Descrição: dc.descriptionDept. of Biology State University of São Paulo (UNESP), Rio Claro-SP-
Descrição: dc.descriptionDept. of Physical Education State University of São Paulo (UNESP), Rio Claro-SP-
Descrição: dc.descriptionDept. of Biology State University of São Paulo (UNESP), Rio Claro-SP-
Formato: dc.format291-301-
Idioma: dc.languageen-
Relação: dc.relationBiology of Sport-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBinding protein (IGFBP-3)-
Palavras-chave: dc.subjectDiabetes Mellitus-
Palavras-chave: dc.subjectGrowth hormone-
Palavras-chave: dc.subjectInsulin-like growth factor (IGF-1)-
Palavras-chave: dc.subjectPhysical training-
Título: dc.titleInfluence of moderate physical training on the GH/IGF-1 axis in diabetic rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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