Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Iowa-
Autor(es): dc.creatorDe Gobbi, Juliana Irani Fratucci-
Autor(es): dc.creatorDe Luca Jr., Laurival Antonio-
Autor(es): dc.creatorJohnson, Alan Kim-
Autor(es): dc.creatorMenani, José Vanderlei-
Data de aceite: dc.date.accessioned2025-08-21T22:02:11Z-
Data de disponibilização: dc.date.available2025-08-21T22:02:11Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2001-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1152/ajpregu.2001.280.5.r1301-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224388-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224388-
Descrição: dc.descriptionInteraction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake. Am J Physiol Regulatory Integrative Comp Physiol 280: R1301-R1307, 2001.-Serotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. In this study, we investigated interactions between 5-HT and CCK into the LPBN to control water and NaCl intake. Male Holtzman rats with cannulas implanted bilaterally in the LPBN were treated with furosemide + captopril to induce water and NaCl intake. Bilateral LPBN injections of high doses of the 5-HT antagonist methysergide (4 μg) or the CCK antagonist proglumide (50 μg), alone or combined, produced similar increases in water and 1.8% NaCl intake. Low doses of methysergide (0.5 μg) + proglumide (20 μg) produced greater increases in NaCl intake than when they were injected alone. The 5-HT2a/2c agonist 2,5-dimetoxy-4-iodoamphetamine hydrobromide (DOI; 5 μg) into the LPBN reduced water and NaCl intake. After proglumide (50 μg) + DOI treatment, the intake was not different from vehicle treatment. CCK-8 (1 μg) alone produced no effect. CCK-8 combined with methysergide (4 μg) reduced the effect of methysergide on NaCl intake. The data suggest that functional interactions between 5-HT and CCK in the LPBN may be important for exerting inhibitory control of NaCl intake.-
Descrição: dc.descriptionDept. of Physiology and Pathology School of Dentistry Paulista State University (UNESP), 14801-903 Araraquara, São Paulo-
Descrição: dc.descriptionDepts. of Psychol. and Pharmacol. E. Cardiovascular Center University of Iowa, Iowa City, IA 52242-1407-
Descrição: dc.descriptionDept. of Physiology and Pathology School of Dentistry UNESP, Rua Humaitá, 1680, 14801-903 Araraquara-SP-
Descrição: dc.descriptionDept. of Physiology and Pathology School of Dentistry Paulista State University (UNESP), 14801-903 Araraquara, São Paulo-
Descrição: dc.descriptionDept. of Physiology and Pathology School of Dentistry UNESP, Rua Humaitá, 1680, 14801-903 Araraquara-SP-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject5-hydroxytryptamine-
Palavras-chave: dc.subjectAngiotensin II-
Palavras-chave: dc.subjectMethysergide-
Palavras-chave: dc.subjectNaCl intake-
Palavras-chave: dc.subjectProglumide-
Palavras-chave: dc.subjectSodium appetite-
Título: dc.titleInteraction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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