Efeitos da associação da clonidina à bupivacaína hiperbárica na anestesia subaracnóidea alta

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBraz, José Reinaldo Cerqueira-
Autor(es): dc.creatorKoguti, Edgar Shiguero-
Autor(es): dc.creatorBraz, Leandro Gobbo-
Autor(es): dc.creatorCroitor, Lorena Brito da Justa-
Autor(es): dc.creatorNavarro, Lais Helena Camacho-
Data de aceite: dc.date.accessioned2025-08-21T20:13:11Z-
Data de disponibilização: dc.date.available2025-08-21T20:13:11Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2003-09-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224364-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224364-
Descrição: dc.descriptionBACKGROUND AND OBJECTIVES: Published data suggest that clonidine, an α2-adrenergic agonist, in association with bupivacaine, may increase the incidence of intraoperative hypotension and bradycardia during high-level spinal anesthesia. This study aimed at determining the synergistic potential of two clonidine doses (45 and 75 μg) and hyperbaric bupivacaine on. characteristics and hemodynamic effects of high-level (T4) spinal anesthesia. METHODS: Participated in this randomized double-blind study, 60 ASA I patients scheduled for lower abdominal and limb surgery. Spinal anesthesia was induced with 17.5 mg (3.5 ml) of 0.5% hyperbaric bupivacaine plus the association of the following drugs: Control group (n = 20) - 0.5 ml isotonic saline solution; Clon 45 group (n = 20) - 45 μg (0.3 ml) clonidine + 0.2 ml isotonic saline solution; and Clon 75 (n = 20) - 75 μg (0.5 ml) clonidine. Surgery was only started when high-level (T4) analgesia was consistently obtained, RESULTS: Sensory and motor block onset did not significantly differ among groups (p > 0.05). Both clonidine doses significantly prolonged analgesic block at T8 and motor block level 3 duration (determined by modified Bromage scale) (p < 0.05). Intraoperative arterial hypotension was observed only in Clon 75 group as compared to Control group (p < 0.05), while Clon 45 group had intermediate incidence between both groups. There was no significant difference among groups in bradycardia (p > 0.05). Both clonidine doses prolonged postoperative analgesia (time from spinal block to first postoperative analgesic request) (p < 0.05). CONCLUSIONS: High clonidine dose (75 μg) associated to hyperbaric bupivacaine during high-level spinal anesthesia (T4) induces a higher incidence of arterial hypotension but prolongs sensory block and postoperative analgesia similar to lower clonidine dose (45 pg) during upper spinal anesthesia.-
Descrição: dc.descriptionDept. Anestesiologia da FMB UNESP, 18618-970 Botucatu, SP-
Descrição: dc.descriptionDept. Anestesiologia da FMB UNESP, 18618-970 Botucatu, SP-
Formato: dc.format561-572-
Idioma: dc.languagept_BR-
Idioma: dc.languageen-
Relação: dc.relationRevista Brasileira de Anestesiologia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnalgesics: clonidine-
Palavras-chave: dc.subjectAnesthetic techniques, Regional: spinal block-
Palavras-chave: dc.subjectAnesthetics: Local: bupivacaine-
Título: dc.titleEfeitos da associação da clonidina à bupivacaína hiperbárica na anestesia subaracnóidea alta-
Título: dc.titleEffects of clonidine associated to hyperbaric bupivacaine during high-level spinal anesthesia-
Tipo de arquivo: dc.typelivro digital-
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