Brazilian individuals with impaired glucose tolerance are characterized by impaired insulin secretion

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv. of Rochester Sch. of Medicine-
Autor(es): dc.creatorPimenta, W. P.-
Autor(es): dc.creatorSantos, M. L.-
Autor(es): dc.creatorCruz, N. S.-
Autor(es): dc.creatorAragon, F. F.-
Autor(es): dc.creatorPadovani, C. R.-
Autor(es): dc.creatorGerich, J. E.-
Data de aceite: dc.date.accessioned2025-08-21T15:19:41Z-
Data de disponibilização: dc.date.available2025-08-21T15:19:41Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2002-12-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224291-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224291-
Descrição: dc.descriptionBackground: To better understand the pathogenesis of type 2 diabetes mellitus, insulin secretion and insulin sensitivity (IS) were evaluated in white Brazilians with impaired glucose tolerance (IGT), using the oral glucose tolerance test (OGTT) and the hyperglycemic clamp technique. Methods: Twenty-five IGT subjects were individually matched with normal glucose-tolerant (NGT) subjects for demographic characteristics. At first, they were submitted to the OGTT and plasma glucose and insulin were measured. Of the 25 pairs, 20 could participate in the hyperglycemic clamp procedures, at a second visit. All participants had their plasma glucose levels equally increased to 180 mg/dl; this was maintained for three hours by variable glucose infusion. During the procedure, plasma glucose and insulin were measured at established intervals. Results: In the postabsorptive state, the IGT subjects presented higher levels of plasma glucose, blood HbA1, and serum triglycerides, but similar plasma insulin levels. After the oral glucose load, early and total insulin release, in relation to glucose levels, were respectively, 43 and 67% lower in the IGT individuals. The index of whole-body IS was increased in the IGT individuals (4.36 ± 1.71 vs 3.61 ± 1.28 mg-1·μU-1·100·ml2; p < 0.05). By the hyperglycemic clamp technique first- (82 ± 26 vs 215 ± 88 μU/ml; p < 0.001) and second- (36 ± 19 vs 73 ± 44 μU/ml; p < 0.05) phases of insulin secretion was decreased in the IGT individuals, especiallythe first one. However, the groups did not differ in relation to the IS: IGT = 13.52 ± 7.27 and NGT = 9.96 ± 6.70 mg·ml/kg·μU·min-1; p > 0.05. Functional relationship of IS (y) on first-phase insulin release (x) showed a smaller (p < 0.05) regression coefficient for the IGT group. Conclusion: Brazilians with IGT well-matched with NGT ones were characterized by impaired first- and second-phase insulin secretion (mainly the former), while defects in IS were not evident.-
Descrição: dc.descriptionDepartment of Internal Medicine School of Medicine São Paulo State University, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Biostatistics Institute of Biosciences São Paulo State University, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Medicine Univ. of Rochester Sch. of Medicine, Rochester, New York-
Descrição: dc.descriptionDepartamento de Clinica Medica Faculdade de Medicina de Botucatu UNESP, Caixa Postal, 584 Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine School of Medicine São Paulo State University, Botucatu, São Paulo-
Descrição: dc.descriptionDepartment of Biostatistics Institute of Biosciences São Paulo State University, Botucatu, São Paulo-
Descrição: dc.descriptionDepartamento de Clinica Medica Faculdade de Medicina de Botucatu UNESP, Caixa Postal, 584 Botucatu, São Paulo-
Formato: dc.format468-476-
Idioma: dc.languageen-
Relação: dc.relationDiabetes and Metabolism-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHyperglycemic clamp-
Palavras-chave: dc.subjectImpaired glucose tolerance-
Palavras-chave: dc.subjectInsulin secretion-
Palavras-chave: dc.subjectInsulin sensitivity-
Palavras-chave: dc.subjectOral glucose stimulus-
Título: dc.titleBrazilian individuals with impaired glucose tolerance are characterized by impaired insulin secretion-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.